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Meg-3 meg-4 mutants are defective in exogenous RNAi signal amplification

ABSTRACT: meg-3 meg-4 mutants are defective in exogenous RNAi signal amplification

PROVIDER: PRJNA555887 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9725710.fastq.gz	Fastqsanger.gz
	SRR9725711.fastq.gz	Fastqsanger.gz
	SRR9725712.fastq.gz	Fastqsanger.gz
	SRR9725703.fastq.gz	Fastqsanger.gz
	SRR9725713.fastq.gz	Fastqsanger.gz

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meg-3 meg-4 mutants are defective in exogenous RNAi signal amplification

Project description:Worms were fed a dsRNA trigger against the pos-1 gene and subjected to sRNAseq to see if they could amplify the exogenous RNAi trigger. meg-3 meg-4 were not able to amplify the signal as robustly as wild-type.

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meg-3 meg-4 upregulate endogenous sRNAs targeting RNAi genes and downregulate their mRNAs

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