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MiR-3607 controls Wnt/bCat pathway to regulate cerebral cortex development

ABSTRACT: miR-3607 controls Wnt/bCat pathway to regulate cerebral cortex development

PROVIDER: PRJNA558388 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR9895152.fastq.gz	Fastqsanger.gz
	SRR9895153.fastq.gz	Fastqsanger.gz
	SRR9895154.fastq.gz	Fastqsanger.gz
	SRR9895155.fastq.gz	Fastqsanger.gz
	SRR9895156.fastq.gz	Fastqsanger.gz

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miR-3607 controls Wnt/bCat pathway to regulate cerebral cortex development

Project description:We report that miR3607 controls the embryonic cerebral cortex development by regulating neurogenesis, neuron migration and axon growth in a bCatenin signaling pathway dependent manner.

2022-01-12 | GSE135321 | GEO

Expression data from mouse cerebral cortex

Project description:Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages Cerebral cortex from two mouse strains [C57BL/6J(B6) and C3H/J (C3H)] at post-natal day 1 (p1) and post-natal 11 weeks (11 wk) were harvested for microarray experiments

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TRNP1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate

Project description:Evolution of the mammalian brain encompassed a remarkable increase in size of cerebral cortex, including tangential and radial expansion, but the mechanisms underlying these key parameters are still largely unknown. Here, we identified the novel DNA associated protein TRNP1 as a regulator of cerebral cortical expansion in both these dimensions. Gain and loss of function experiments in the mouse cerebral cortex in vivo demonstrate that high Trnp1 levels promote neural stem cell self-renewal and tangential expansion, while lower levels promote radial expansion resulting in a potent increase in the generation of intermediate progenitors and outer radial glial cells resulting in folding of the otherwise smooth murine cerebral cortex. Remarkably, TRNP1 expression levels exhibit regional differences also in the cerebral cortex of human fetuses anticipating radial or tangential expansion respectively. Thus, the dynamic regulation of TRNP1 is critical to regulate tangential and radial expansion of the cerebral cortex in mammals. We performed gene expression microarray analysis on embryonic mouse cerebral cortex derived from Trnp1 knockdown and control animals.

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Expression data from mouse cerebral cortex

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Metabolomic signature of mouse cerebral cortex following Toxoplasma gondii infection

Project description:BACKGROUND: The protozoan parasite Toxoplasma gondii infects and alters the neurotransmission in cerebral cortex and other brain regions, leading to neurobehavioral and neuropathologic changes in humans and animals. However, the molecules that contribute to these changes remain largely unknown.METHODS: We have investigated the impact of T. gondii infection on the overall metabolism of mouse cerebral cortex. Mass-spectrometry-based metabolomics and multivariate statistical analysis were employed to discover metabolomic signatures that discriminate between cerebral cortex of T. gondii-infected and uninfected control mice.RESULTS: Our results identified 73, 67 and 276 differentially abundant metabolites, which were involved in 25, 37 and 64 pathways at 7, 14 and 21 days post-infection (dpi), respectively. Metabolites in the unsaturated fatty acid biosynthesis pathway were upregulated as the infection progressed, indicating that T. gondii induces the biosynthesis of unsaturated fatty acids to promote its own growth and survival. Some of the downregulated metabolites were related to pathways, such as steroid hormone biosynthesis and arachidonic acid metabolism. Nine metabolites were identified as T. gondii responsive metabolites, namely galactosylsphingosine, arachidonic acid, LysoSM(d18:1), L-palmitoylcarnitine, calcitetrol, 27-Deoxy-5b-cyprinol, L-homophenylalanine, oleic acid and ceramide (d18:1/16:0).CONCLUSIONS: Our data provide novel insight into the dysregulation of the metabolism of the mouse cerebral cortex during T. gondii infection and have important implications for studies of T. gondii pathogenesis.

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Protocadherin 8 and transcription factor Dbx1 regulate the formation of developing cerebral cortex

Project description:Protocadherin 8 and transcription factor Dbx1 regulate the formation of developing cerebral cortex

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TRNP1 regulates expansion and folding of the mammalian cerebral cortex by control of radial glial fate

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Human and Rhesus macaque cerebral cortex DNA methylation by MeDIP-Chip

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2012-03-01 | E-GEOD-27461 | biostudies-arrayexpress

Expression data from mouse cerebral cortex

Project description:Expression data from mouse cerebral cortex

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