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Nanostring miRNA expression profiling analysis for QKI-5 knockdown H1299 cells and control cells

ABSTRACT: Nanostring miRNA expression profiling analysis for QKI-5 knockdown H1299 cells and control cells

PROVIDER: PRJNA558542 | ENA |

REPOSITORIES: ENA

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Nanostring miRNA expression profiling analysis for QKI-5 knockdown H1299 cells and control cells

Project description:We used the NanoString Human nCounter miRNA expression platform to compare the miRNA expression profiles of QKI-5 knockdown H1299 cells and control cells We found that QKI-5 knockdown significantly changed miRNA expression pattern in lung cancer cells

2021-08-01 | GSE135348 | GEO

Analysis of gene expression in QKI knockdown CG-4 cells

Project description:QKI is required for myelin formation in the verterbrate brain. It functions by binding RNA and regulating its stability, translation, and/or aternative splicing. We have used Affymetrix exon arrays to assess changes in gene expression in response to QKI knockdown on an exon level in rat CG-4 oligodendrocyte precursor cells. Knockdown cells were compared to control cells. Knockdown groups included QKI siRNA transfection, QKI shRNA stable transfection, and hnRNP A1 transient transfection. Control groups consisted of untransfected, control siRNA transfection, control shRNA stable transfection. Each group was analyzed in triplicate.

2011-01-20 | E-GEOD-26716 | biostudies-arrayexpress

Analysis of gene expression in QKI knockdown CG-4 cells

2011-01-20 | GSE26716 | GEO

Genomewide analysis of QKI-dependent alternative splicing

Project description:To identify QKI targets, we performed QKI knockdown in BEAS2B cells and analyzed alternative splicing patterns by high-throughput RNA sequencing. The mRNA profiles of control- and QKI-knockdown BEAS2B cells were generated by deep sequencing using Illumina GAIIx sequencer.

2014-04-14 | E-GEOD-55215 | biostudies-arrayexpress

Knockdown of EIF3G inhibits the intracellular protein translation of H1299 cells

Project description:eIF3 is the largest translation initiation factor in mammalian cells, consisting of 13 subunits. This translation initiation factor is involved in multiple processes of protein translation in cells, including translation initiation, termination, and ribosome recycling. Several studies have reported that multiple subunits of eIF3 exhibit abnormal expression in tumor cells and play an important role in the occurrence and development of tumors. In this study, it was found that changes in the expression level of EIF3G significantly affected the growth of non-small cell lung cancer. Knockdown of EIF3G inhibited the intracellular protein translation process of non-small cell lung cancer cells H1299. Through the study of translatome, it was found that knockdown of EIF3G significantly affected the cell cycle processes in H1299 cells. In vitro cell experiments also showed that changes in the expression level of EIF3G influences the cell cycle distribution of H1299 cells. This study is the first to explore the impact of knockdown of EIF3G on the translatome of H1299 cells.

2024-06-30 | GSE234080 | GEO

Exosomes of p53 mutant H1299 cells

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2018-12-04 | PXD011241 | Pride

MiRNA microarray for exosome of H1299 cells after irradiation

Project description:Objective: to find out the exosome miRNA of H1299 cells that can be changed by ionizing radiation

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Expression data from NCI-H1299 and NCI-H1299/CDDP cells

Project description:Expression data from NCI-H1299 and NCI-H1299/CDDP cells

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QKI and miR-155 in inflammation and leukemogenesis

Project description:Transcription profiling by array of siRNA against Quaking (QKI) transcripts to identify transcripts that are modulated by QKI activity. MiR-155 is an oncogene and we report here that it targets QKI transcripts. Therefore, we believe that QKI acts as a tumor suppressor gene in different leukemias. We ablated the expression of QKI transcripts using siRNAs in order to further elucidate the effects of QKI in leukemogenesis, and how miR-155 and QKI functionally interact with each other.

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Expression data from mRNAs co-precipitated with QKI in SW480 cells

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2023-03-21 | GSE227471 | GEO

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