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Human neutrophils stimulated with IL-13.

ABSTRACT: Human neutrophils stimulated with IL-13.

PROVIDER: PRJNA558811 | ENA |

REPOSITORIES: ENA

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Human neutrophils stimulated with IL-13.

Project description:Studying the effect of Th2 cytokine IL13 on on gene expression of human neutrophils by comparing gene expression of neutrophiles isolated from the blood of 3 healthy donors and stimulated with IL-13 (10ng/ml) or left unstimulated.

2023-03-28 | GSE135426 | GEO

Human neutrophils stimulated with IL-4.

Project description:Human neutrophils stimulated with IL-4.

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Human neutrophils stimulated with IL-4.

Project description:Studying the effect of Th2 cytokine IL4 on gene expression of human neutrophils by comparing gene expression of neutrophils isolated from the blood of 3 healthy donors and stimulated with IL-4 (1ng/ml) or left unstimulated.

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Neutrophil activation by IL-4, IL-13 and IFN-g

Project description:Interleukin (IL)-4 and IL-13 are related cytokines with well-known roles in type 2 immune response. However, their effects on neutrophils are less defined and existing research has provided somewhat contradictory results We measured IL-4-, IL-13- and IFN-g-stimulated gene expression in highly purified human neutrophils.

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IL-13 Stimulated Esophageal Epithelial miRNA

Project description:miRNA profiling of unstimulated and IL-13 stimulated esophageal epithelial cells

2012-06-26 | E-MEXP-3351 | biostudies-arrayexpress

Transcription profiling by array of human bronchial epithelial cells stimulated with IL-13

Project description:Human bronchial epithelial cells were stimulated without or with 100 ng/mL IL-13 for 24 hours.

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Transcription profiling of human eosinophilic esophagitis biopsies, cultured and stimulated with IL-13

Project description:3 eosinophilic esophagitis biopsies, cultured and stimulated with IL-13 : each of them was either left unstimulated or stimulated (100ng for 48h); We used microarray to uncover the IL-13-induced genes in esophageal epithelial cells of the esophagus Experiment Overall Design: 3 biopsies from EE patients were obtained and primary epithelial cell were cultured and either left unstimulated or stimulated with IL-13 followed by RNA extraction and hybridization on Affymetrix microarrays.

2008-06-20 | E-GEOD-8853 | biostudies-arrayexpress

Expression profiling of IL-13 stimulated PBMCs with and without an IL-13R antagonist

Project description:This experiment aims to identify the biological pathways and diseases associated with the cytokine Interleukin 13 (IL-13) using gene expression measured in peripheral blood mononuclear cells (PBMCs). The experiment comprised of samples obtained from 3 healthy donors. The expression profiles of in vitro IL-13 stimulation were generated using RNA-seq technology for 3 PBMC samples at 24 hours. The transcriptional profiles of PBMCs without IL-13 stimulation were also generated to be used as controls. An IL-13R-alpha antagonist (Redpath et al. Biochemical Journal, 2013) was introduced into IL-13 stimulated PBMCs and the gene expression levels after 24h were profiled to examine the neutralization of IL-13 signaling by the antagonist.

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Lipopolysaccharide-stimulated neutrophils

Project description:Neutrophil gene transcription following lipopolysaccharide exposure. Microarray analysis of lipopolysaccharide-treated human neutrophils. Neutrophils respond to infection by degranulation, release of reactive oxygen intermediates, and secretion of chemokines and cytokines; however, activation of neutrophil transcriptional machinery has been little appreciated. Recent findings suggest that gene expression may represent an additional neutrophil function after exposure to lipopolysaccharide (LPS). We performed microarray gene expression analysis of 4,608 mostly nonredundant genes on LPS-stimulated human neutrophils. Analysis of three donors indicated some variability but also a high degree of reproducibility in gene expression. Twenty-eight verifiable, distinct genes were induced by 4 h of LPS treatment, and 13 genes were repressed. Genes other than cytokines and chemokines are regulated; interestingly, genes involved in cell growth regulation and survival, transcriptional regulation, and interferon response are among those induced, whereas genes involved in cytoskeletal regulation are predominantly repressed. In addition, we identified monocyte chemoattractant protein-1 as a novel LPS-regulated chemokine in neutrophils. Included in these lists are five clones with no defined function. These data suggest molecular mechanisms by which neutrophils respond to infection and indicate that the transcriptional potential of neutrophils is greater than previously thought.

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