Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

An ontogenetic switch in the positive and negative selection of B cells [B cell subsets]

ABSTRACT: An ontogenetic switch in the positive and negative selection of B cells [B cell subsets]

PROVIDER: PRJNA559546 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR9942500_1.fastq.gz	Fastqsanger.gz
	SRR9942500_2.fastq.gz	Fastqsanger.gz
	SRR9942510_1.fastq.gz	Fastqsanger.gz
	SRR9942510_2.fastq.gz	Fastqsanger.gz
	SRR9942501_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 40

Similar Datasets

An ontogenetic switch in the positive and negative selection of B cells [B cell subsets]

Project description:Developing B cells can differentiate into a variety of different subsets, but the mechanisms that determine these outcomes are incompletely understood, with theories based on separate lineages or the positive and negative selection by self-antigens. In particular, the development of the B-1 B cell subset arises mainly from precursors in early ontogeny and is subject to positive selection by self-antigens, whereas the follicular B-2 B cell subset arises later and is subject to negative control. In this study we show how a cell intrinsic switch from Lin28b to Let7 gene expression changes a B cell’s susceptibility from positive to negative selection during ontogeny. Ectopic expression of a Lin28b transgene in B cells restores the positive selection of autoreactive B-1 B cells by self-antigen in adult bone marrow. Analysis of antigen-specific immature B cells in early and late ontogeny identifies Lin28b-dependent genes associated with B-1 B cell development, including Arid3a and Bhleh41, and Lin28b-independent effects associated with the presence or absence of self-antigen. These findings identify cell intrinsic and extrinsic determinants of B cell fate during ontogeny and reconcile lineage and selection theories of B cell development. They explain how changes in the balance of positive and negative selection may be able to adapt to meet the immunological needs of an individual during its lifetime.

2020-02-26 | GSE135649 | GEO

An ontogenetic switch in the positive and negative selection of B cells

Project description:An ontogenetic switch in the positive and negative selection of B cells

| PRJNA559543 | ENA

An ontogenetic switch in the positive and negative selection of B cells [IgHEL]

Project description:An ontogenetic switch in the positive and negative selection of B cells [IgHEL]

| PRJNA559547 | ENA

An ontogenetic switch in the positive and negative selection of B cells [IgHEL]

2020-02-26 | GSE135648 | GEO

An ontogenetic switch in the positive and negative selection of B cells [bone marrow and fetal liver]

2020-02-26 | GSE135224 | GEO

An ontogenetic switch in the positive and negative selection of B cells [bone marrow and fetal liver]

Project description:An ontogenetic switch in the positive and negative selection of B cells [bone marrow and fetal liver]

| PRJNA557934 | ENA

An ontogenetic switch drives the positive and negative selection of B cells.

Project description:Developing B cells can be positively or negatively selected by self-antigens, but the mechanisms that determine these outcomes are incompletely understood. Here, we show that a B cell intrinsic switch between positive and negative selection during ontogeny is determined by a change from Lin28b to let-7 gene expression. Ectopic expression of a Lin28b transgene in murine B cells restored the positive selection of autoreactive B-1 B cells by self-antigen in adult bone marrow. Analysis of antigen-specific immature B cells in early and late ontogeny identified Lin28b-dependent genes associated with B-1 B cell development, including Arid3a and Bhleh41, and Lin28b-independent effects are associated with the presence or absence of self-antigen. These findings identify cell intrinsic and extrinsic determinants of B cell fate during ontogeny and reconcile lineage and selection theories of B cell development. They explain how changes in the balance of positive and negative selection may be able to adapt to meet the immunological needs of an individual during its lifetime.

| S-EPMC7035474 | biostudies-literature

An ontogenetic switch in the positive and negative selection of B cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-02-26 | GSE135650 | GEO

Lin28b controls a neonatal to adult switch in B cell positive selection

Project description:Lin28b controls a neonatal to adult switch in B cell positive selection

| PRJNA559395 | ENA

Autofluorescence positive and negative microglia constitute novel subsets found in healthy brain.

Project description:Utilizing autofluorescence (AF) as a discriminating parameter, we identified two novel microglia subsets in both mice, termed autofluorescence-positive (AF+) and negative (AF-), and characterized them by label-free proteomics.

2020-06-26 | PXD017505 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data