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Expression data of LN229 cells treated with 23 Pa compressive solid stress (CSS) or no CSS

ABSTRACT: Expression data of LN229 cells treated with 23 Pa compressive solid stress (CSS) or no CSS

PROVIDER: PRJNA564814 | ENA |

REPOSITORIES: ENA

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Expression data of LN229 cells treated with 23 Pa compressive solid stress (CSS) or no CSS

Project description:Glioblastoma ( GBM) is an astrocytic brain tumor with median survival times of < 15 months, primarily as a result of high infiltrative potential and development of resistance to therapy (i.e., surgical resection, chemoradiotherapy). A prominent feature of the GBM microenvironment is compressive solid stress (CSS) caused by uninhibited tumor growth within the confined skull. We used microarrays to explore the gene expression of LN229 cells treated with 23 Pa CSS as compared to no CSS. The purpose is to detect the up-regulated genes induced by CSS.

2019-12-31 | GSE137210 | GEO

Differential gene expression of static and intermittent compressive force treated human periodontal ligament cells

Project description:Mechanical force has been shown to regulate periodontal ligament cells (PDLs) behaviors. However, different force types lead to distinct PDLs’ responses. Here, the differential gene expression profiling of PDLs subjected to static and intermittent compressive forces was examined using RNA sequencing technique. Results demonstrated that the static and intermittent compressive force treated PDLs exhibited the differential regulation genes. KEGG pathway enrichment analysis revealed that focal adhesion and transforming growth factor beta signaling pathway were commonly upregulated while calcium signaling pathway was downregulated in both static and intermittent compressive force-treated PDLs. Interestingly, Wnt signaling pathway was upregulated only in the PDLs that subjected to the intermittent compressive force.

2019-07-23 | GSE112122 | GEO

Intracellular free zinc mediates compressive stress-induced mechanotransduction in pancreatic cancer

Project description:In this study, Nihei et al. show that unknown function of the intracellular free zinc in mechanical compressive stress-induced signaling and altered gene expression in pancreatic cancer cells, provide novel perspectives on zinc as a signal transducer and therapeutic target. We explored the roles of compressive stress in pancreatic cancer progression by investigating the changes in gene expression induced by it using microarray.

2022-08-01 | GSE196275 | GEO

Acidiphilium sp. PA strain:PA

Project description:Acidiphilium sp. PA strain:PA Genome sequencing and assembly

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Comparative RNAseq of human WT and PARP3-/- LN229 cells

Project description:To identify the biological pathways regulated by PARP3, RNAseq of the WT and PARP3-/- LN229 human glioblastoma cells were performed. Samples were collected from subconfluent cells for total RNA isolation and RNA sequencing

2022-09-21 | GSE173801 | GEO

Differential gene expression of intermittent compressive force treated mouse gingival fibrpblast derived induced pluripiotent stem cells

Project description:Mechanical force regulates various biological responses in many cell types. Here, the retinoic acid treated mouse gingival fibroblast derived induced pluripotent stem cells were treated with intermittent compressive for 24 h and gene expression profiling was evaluated using RNA sequencing technique. Results indicated that intermittent compressive stress regulated various pathways in these cells including p53 signaling and other metabolic pathways.

2021-12-31 | GSE118952 | GEO

The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force

Project description:To explore the lncRNA landscape of periodontal ligament stem cells (PDLSCs) subjected to compressive force.

2021-07-09 | GSE116787 | GEO

Effect of formate on LN229 cells

Project description:Effect of formate on LN229 cells

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Transcriptomic analysis of LN229 cell treated by unit of bortezomib and panobinostat

Project description:We report the application of unit of bortezomib and panobinostat on LN229 cell , and further explored the mechanism of drugs on GBM cells.

2022-06-30 | GSE206984 | GEO

Effects of dynamic compressive loading on MSC chondrogenesis

Project description:Long-term dynamic compression enhanced the mechanical properties of MSC-seeded constructs only when loading was initiated after 21 days of chondrogenic differentiation. This study examined the molecular differences of chondrogenic MSCs compared to undifferentiated MSCs (TGF-beta vs no TGF-beta) and the effects of dynamic loading on MSC chondrogenesis (loading vs free-swelling). Free-swelling MSC-seeded constructs were cultured for 21 days in chemically defined media. Chondrogenesis was induced with TGF-beta3. Undifferentiated controls were maintained in parallel. After 21 days of chondrogenic differentiation, a subset of constructs were subjected to 21 days of dynamic compressive loading. On days 21 and 42, construct mechanical properties and biochemical content were assessed. Microarray analysis was carried out on day 3, day 21 and day 42 constructs. 6 arrays.

2010-11-01 | E-GEOD-18879 | biostudies-arrayexpress

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