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Origin of kidney papillary tumors from renal progenitors

ABSTRACT: Origin of kidney papillary tumors from renal progenitors

PROVIDER: PRJNA566015 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10134767.fastq.gz	Fastqsanger.gz
	SRR10134768.fastq.gz	Fastqsanger.gz
	SRR10134769.fastq.gz	Fastqsanger.gz
	SRR10134770.fastq.gz	Fastqsanger.gz
	SRR10134771.fastq.gz	Fastqsanger.gz

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Origin of kidney papillary tumors from renal progenitors

Project description:Purpose: Using single-cell RNA sequencing (scRNAseq), Young et al. (Science, 2018, PMID 30093597) recently identified a canonical cancer transcriptome as the possible cell of origin of papillary renal cell carcinoma (pRCC) that matched a rare proximal convoluted tubular cell population characterized as VCAM1+ SLC17A3+ SLC7A13-, a cell cluster signature defined as PT1. The goal of this study is to compare pRCC transcriptome to human renal progenitor cell (RPC) transcriptome. Methods: To compare the pRCC cells with PT1 features to our RPC population, we analyzed Young pRCC scRNAseq data set together with scRNAseq data obtained from human RPC cultures. Results: The PT1 signature that characterizes the cell of origin of pRCC identifies a RPC cluster. Conclusions: These results suggest that the cell of origin of pRCC corresponds to RPCs.

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Analysis of microRNA expression profiles in clear cell papillary renal cell carcinoma compared to normal adjacent tissue.

Project description:Clear cell papillary renal cell carcinoma (CCPRCC) is a low-grade renal neoplasm with morphological characteristics mimicking both clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC). However, despite some overlapping features, their morphological, immunohistochemical, and molecular profiles are distinct. To better understand the biology of this tumor, we analyze the miRNA expression profiles of a set of CCPRCC by microarrays.

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Gene expression of papillary renal neoplasm with reverse polarity (PRNRP) cases + PRCC cases

Project description:Between 80% and 90% of renal carcinomas are either clear cell renal cell carcinoma or papillary RCC although there are at least 20 other distinct forms of RCC recognised by the World Health Organization (WHO). Emerging or provisional entities have been considered as variants of PRCC, including papillary renal neoplasm with reversed polarity (PRNRP). However, the molecular basis of PRNRP is unknown. We used microarray analysis to elucidate the gene profile of 10 PRNRP cases and an additional 7 PRCC cases. Cases were only considered for this study after fulfilment of strict inclusive histological and immunohistochemical criteria. We used Affymetrix Clariom D human arrays to elucidate the expression of these samples.

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Project description:We aimed to use next-generation sequencing that may provide intriguing insights into the molecular pathways mediating anti-tumor activity for HSP90 inhibitor, SNX2112 in papillary renal cancer. Our findings uncovered unique set of target genes and pathways of significance in papillary renal cancer that have potential to be translated into clinically effective therapeutic strategies for patients.

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