Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Effects of Overexpression of Dube3a in Drosophila Brain

ABSTRACT: Effects of Overexpression of Dube3a in Drosophila Brain

PROVIDER: PRJNA576394 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10244500.fastq.gz	Fastqsanger.gz
	SRR10244501.fastq.gz	Fastqsanger.gz
	SRR10244502.fastq.gz	Fastqsanger.gz
	SRR10244503.fastq.gz	Fastqsanger.gz
	SRR10244504.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 9

Similar Datasets

Nab2 Drosophila pupal brain LC-MSMS

Project description:We exploit the predictable time course of Drosophila brain development to perform a temporally coupled quantitative proteomic analysis of the pupal brain in Nab2 mutant or overexpression models, which reveals that Nab2 is required to regulate the abundance of a number of proteins with critical roles in Drosophila neurons. Pupal brains lacking Nab2 show dysregulation of proteins, such as Futsch, Turtle, Contactin, and Van Gogh, that typically function in brain morphogenesis, neuroblast proliferation, circadian sleep/wake cycle, and other neurodevelopmental processes. Overall, these data define a role for Nab2 during neurodevelopment in regulating protein abundance for a subset of the brain proteome and provide a window into the potential functions of human ZC3H14 protein.

2022-02-17 | PXD022984 | Pride

Effects of Overexpression of Dube3a in Drosophila Brain

Project description:Fly Dube3a was expressed using either the neuronal driver (elav-GAL4) or the glial driver (Repo-GAL4). RNAseq data was compared among groups (elav>Dube3a), (repo>Dube3a) and (Dube3a alone). Expression was measured in whole dissected fly brain.

2019-12-31 | GSE138562 | GEO

piwi mutations and c-Fos overexpression on Drosophila ovarian germline

Project description:This project aims to identify molecular effects of piwi mutations and c-Fos overexpression on the formation of Drosophila ovarian germline RNA-seq was utilized to compare transcript levels between wild type, piwi mutant, and c-Fos over-expressing ovarian tissues

2017-02-08 | GSE69722 | GEO

Effects of agouti overexpression in the brain and skin transcriptome of zebrafish

Project description:Twenty transgenic fish overexpressing agouti-signaling protein (ASIP, Ceinos et al., Pigment Cell and Melanoma Research 28:196-209, 2015) and wild type (WT) zebrafish were placed in 6-liter tanks and acclimated during 30 days prior to sampling to minimize physiological differences. Animals were sacrificed and the brain+pituitary and the skin dissected under the stereo microscope, placed in trizol and stored at -80C until RNA extraction. Six biological replicates (3 females and 3 males) of each tissue (skin and brain) of each group (ASIP vs WT) were analyzed in a total of 6 slides containing 4 microarrays in the 4 × 44 k format. Global gene expression analyses were performed to search for both sex-dependent and transgene-dependent effects as well as the interaction between both factors (sex x phenotype) on the brain+pituitary and skin transcriptome. Wild type (Tu) or transgenic zebrafish overexpression agouti-signaling protein (ASIP) were reared in similar conditions. Brain+pituitary and skin were sampled from 6 ASIP (3 males + 3 females) and WT (3 males + 3 females) zebrafish. Samples were individually hybridized in a total of 6 slides containing 4 microarrays in the 4 × 44 k format. Microarrays included 60-mer probes to the unique transcripts from Ensembl and Unigene which were annotated by functional categories of GO and pathways of KEGG with bioinformatics package STARS

2015-09-11 | E-GEOD-72908 | biostudies-arrayexpress

Effects of RDD4 overexpression in leaf sheaths

Project description:Effects of RDD4 overexpression in leaf sheaths

| PRJNA674823 | ENA

Polyploidy in the adult Drosophila melanogaster brain

Project description:To understand gene expression changes in different regions of the Drosophila brain with age, we performed RNAseq different regions of the adult drosophila CNS at different ages.

2020-06-25 | GSE153165 | GEO

Drosophila brain O-GlcNAc proteome

Project description:O-GlcNAcylation is a dynamic post-translational modification that diversifies the proteome with spatiotemporal precision in response to various stimuli. Its dysregulation is associated with many neurological disorders that impair cognitive function, and yet identification of phenotype-relevant protein substrates in specific brain regions remains unfeasible. By combining O-GlcNAc binding activity of Clostridium perfringens OGA (CpOGA) with TurboID proximity labeling, we developed an O-GlcNAcylation profiling tool that translates O-GlcNAc modification into biotin conjugation for tissue-specific substrates enrichment. We mapped the O-GlcNAcylated proteome in different brain regions of Drosophila.

2024-04-10 | PXD040412 | Pride

miR-975 overexpression effect on Drosophila cell lines

Project description:miR-975 overexpression effect on Drosophila cell lines

| PRJNA419952 | ENA

Overexpression of brain endothelial mucin-type O-glycan biosynthesis promotes brain homeostasis in aged mice

Project description:In our study, we find that AAV-mediated brain endothelial B3GNT3 overexpression reduces neuroinflammatory markers and cognitive deficits in aged mice. Here, we perform snRNA-seq to characterize the cellular and molecular changes induced by brain endothelial B3GNT3 overexpression.

2024-12-17 | GSE268642 | GEO

Effects of miRNA overexpression on keratinocytes in mice

Project description:Effects of miRNA overexpression on keratinocytes in mice

| PRJNA818981 | ENA