Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node

ABSTRACT: Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node

PROVIDER: PRJNA576470 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node I

Project description:Obesity has emerged as a worldwide problem in human health. Dietary lipids are taken up and transported via lymphatics into the circulatory system. During this process, lipids pass the mesenteric lymph node (mLN). These organs filter the lymph fluid for foreign antigens to induce and control immune responses. Alteration of that function during obesity has only slightly been studied. Here, we characterize changes within the microarchitecture of the mLN during high levels of lipid transport and highlight the role of stromal cells. Microarray experiments detected gene probes expressed by mLN stromal cells. Transmission electron microscopy enabled us to identify lipid droplets in different stromal cells, and in macrophages. Sizes, numbers and intercellular distances increased after 10 weeks of a high-fat diet. Thus, we propose that changes in the microarchitecture and increased accumulation of lipid droplets in stromal cells and macrophages have an influence on the immunological function of the mLN.

2020-05-14 | GSE138593 | GEO

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node II

2020-05-14 | GSE138594 | GEO

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node II

Project description:Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node II

| PRJNA576476 | ENA

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node I

Project description:Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node I

| PRJNA576475 | ENA

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-05-14 | GSE138595 | GEO

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of mesenteric lymph nodes.

Project description:In obesity, increased dietary lipids are taken up and transported by the lymphatic systems into the circulatory system. Increased fat accumulation results in impairments in the lymph fluid and lymph node (LN) atrophy. LNs filter the lymph fluid for foreign antigens to induce and control immune responses, and the alteration of this function during obesity remains underexplored. Here, the changes within the microarchitecture of mesenteric LNs (mLNs) during high levels of lipid transport were investigated, and the role of stromal cells in mice fed a high-fat diet for 10 weeks was assessed. Microarray experiments revealed that gene probes involved in lipid metabolism are expressed by mLN stromal cells. Transmission electron microscopy enabled the identification of lipid droplets in lymphatic endothelial cells, different reticulum cells, and macrophages, and the lipid droplet sizes as well as their numbers and intercellular distances increased after 10 weeks of high-fat diet feeding. The results indicate that changes in the microarchitecture and increased accumulation of lipid droplets in stromal cells and macrophages influence the immunological function of mLNs.

| S-EPMC7210474 | biostudies-literature

Bone Microarchitecture

Project description:Bone Microarchitecture

| PRJNA671150 | ENA

Bone Microarchitecture

Project description:Bone Microarchitecture

| PRJNA671151 | ENA

GNPS - Mouse Mesenteric Lymph Node Metabolites

Project description:Small molecules extracted from mouse mesenteric lymph nodes.

| MSV000080181 | GNPS

Transcriptomes of mesenteric lymph node WT and Tph1-deficient ILC2s

Project description:RNA sequencing of mesenteric natural and inflammatory ILC2s sorted from Il7rCre/+ Tph1flox/flox or Il7rCre/+ control mice-infected with N. brasiliensis

2020-04-21 | GSE145287 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data