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Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node I

ABSTRACT: Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node I

PROVIDER: PRJNA576475 | ENA |

REPOSITORIES: ENA

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Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node II

Project description:Obesity has emerged as a worldwide problem in human health. Dietary lipids are taken up and transported via lymphatics into the circulatory system. During this process, lipids pass the mesenteric lymph node (mLN). These organs filter the lymph fluid for foreign antigens to induce and control immune responses. Alteration of that function during obesity has only slightly been studied. Here, we characterize changes within the microarchitecture of the mLN during high levels of lipid transport and highlight the role of stromal cells. Microarray experiments detected gene probes expressed by mLN stromal cells. Transmission electron microscopy enabled us to identify lipid droplets in different stromal cells, and in macrophages. Sizes, numbers and intercellular distances increased after 10 weeks of a high-fat diet. Thus, we propose that changes in the microarchitecture and increased accumulation of lipid droplets in stromal cells and macrophages have an influence on the immunological function of the mLN.

2020-05-14 | GSE138594 | GEO

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node I

2020-05-14 | GSE138593 | GEO

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node

Project description:Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node

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Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node II

Project description:Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node II

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Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of the mesenteric lymph node

Project description:This SuperSeries is composed of the SubSeries listed below.

2020-05-14 | GSE138595 | GEO

Dietary lipids accumulate in macrophages and stromal cells and change the microarchitecture of mesenteric lymph nodes.

Project description:In obesity, increased dietary lipids are taken up and transported by the lymphatic systems into the circulatory system. Increased fat accumulation results in impairments in the lymph fluid and lymph node (LN) atrophy. LNs filter the lymph fluid for foreign antigens to induce and control immune responses, and the alteration of this function during obesity remains underexplored. Here, the changes within the microarchitecture of mesenteric LNs (mLNs) during high levels of lipid transport were investigated, and the role of stromal cells in mice fed a high-fat diet for 10 weeks was assessed. Microarray experiments revealed that gene probes involved in lipid metabolism are expressed by mLN stromal cells. Transmission electron microscopy enabled the identification of lipid droplets in lymphatic endothelial cells, different reticulum cells, and macrophages, and the lipid droplet sizes as well as their numbers and intercellular distances increased after 10 weeks of high-fat diet feeding. The results indicate that changes in the microarchitecture and increased accumulation of lipid droplets in stromal cells and macrophages influence the immunological function of mLNs.

| S-EPMC7210474 | biostudies-literature

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