Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tumour-exposed Tregs from IL33 genetical deficient mice

ABSTRACT: Tumour-exposed Tregs from IL33 genetical deficient mice

PROVIDER: PRJNA577649 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10279659_1.fastq.gz	Fastqsanger.gz
	SRR10279659_2.fastq.gz	Fastqsanger.gz
	SRR10279660_1.fastq.gz	Fastqsanger.gz
	SRR10279660_2.fastq.gz	Fastqsanger.gz
	SRR10279661_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 24

Similar Datasets

Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

| PRJNA577661 | ENA

Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

| PRJNA577660 | ENA

Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Our purpose was to analyse the transcriptomic profile of Tregs from tumor-draining lymph nodes of melanoma-bearing mice in order to understand the functional difference between WT and il33-/- Tregs

2019-10-16 | GSE138872 | GEO

Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Our purpose was to analyse the chromatin landscape of Tregs from tumor-draining lymph nodes of melanoma-bearing mice in order to understand the functional difference between WT and il33-/- Tregs

2019-10-16 | GSE138871 | GEO

Tumour-exposed Tregs from IL33 genetical deficient mice

Project description:This SuperSeries is composed of the SubSeries listed below.

2019-10-16 | GSE138874 | GEO

Proteomic analysis of IL33-proximal proteins in squamous cell carcinoma cells

Project description:Focal adhesion kinase (FAK) is required for the expression of pro-inflammatory genes that inhibit anti-tumour immunity. Here, we show a novel and crucial role for the dual-function cytokine IL33 in FAK-dependent immune evasion. Specifically, nuclear FAK is required for the expression of IL33, the chemokine Ccl5 and the soluble form of the IL33 receptor, sST2, which are required for evasion of CD8+ T-cell-mediated anti-tumour immunity. Mechanistically, nuclear IL33 associates with FAK and a network of chromatin modifiers and transcriptional regulators, including Taf9, WDR82 and BRD4, while sST2 likely negates effects of IL33 secreted into the tumour microenvironment by infiltrating host immune cells. Finally, protein interaction network analysis implies that nuclear FAK–IL33 complexes impact on transcription factors that regulate NFkB and chemokines like Ccl5 downstream. Our data therefore provide new mechanistic insight into how FAK controls the tumour immune environment via a FAK–IL33/sST2 pathway and demonstrate a novel role for nuclear IL33 downstream of FAK as a component of transcription regulatory complexes that critically modulate anti-tumour immunity.

2017-12-06 | PXD007698 | Pride

Gene expression profile of regulatory T cells (Tregs) isolated from visceral adipose tissue and lymph nodes of mice sufficient and deficient of Pparg expression in Tregs

Project description:We identified Pparg as a major orchestrator of the phenotype of adipose-tissue resident regulatory T cells (VAT Tregs). To establish the role of Pparg in shaping the VAT Tregs gene profile and cell dynamics, Tregs from lymph nodes and visceral adipose tissue of mice sufficient and deficient of Pparg expression in Tregs were double sorted for microarray analysis. All gene expression profiles were obtained from highly purified (double-sorted) T cell populations sorted by flow cytometry. To reduce variability, cells from multiple mice were pooled. Triplicates were generated for all groups. Raw data were preprocessed with the RMA algorithm in GenePattern and averaged expression values were used for analysis.

2012-05-03 | E-GEOD-37532 | biostudies-arrayexpress

Gene expression profile of regulatory T cells (Tregs) isolated from visceral adipose tissue and lymph nodes of mice sufficient and deficient of Pparg expression in Tregs

2012-05-04 | GSE37532 | GEO

Gene expression from WT and Id2-deficient Tregs from adipose tissue and spleen

Project description:We report the gene expreesion changes that occur in regulatory T cells (Tregs) isolated from the spleen and visceral adipose tissue of mice that were either WT orI d2-deficient

2019-05-22 | GSE131591 | GEO

Transcriptional analysis of LAG3 deficient Tregs in an inflamed CNS

Project description:Transcriptional analysis of LAG3 deficient Tregs in an inflamed CNS

| PRJNA668390 | ENA