Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

ABSTRACT: Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

PROVIDER: PRJNA577660 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR10279659_1.fastq.gz	Fastqsanger.gz
	SRR10279659_2.fastq.gz	Fastqsanger.gz
	SRR10279660_1.fastq.gz	Fastqsanger.gz
	SRR10279660_2.fastq.gz	Fastqsanger.gz
	SRR10279661_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 12

Similar Datasets

Transposition of native chromatin (ATACseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Our purpose was to analyse the chromatin landscape of Tregs from tumor-draining lymph nodes of melanoma-bearing mice in order to understand the functional difference between WT and il33-/- Tregs

2019-10-16 | GSE138871 | GEO

Tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Tumour-exposed Tregs from IL33 genetical deficient mice

| PRJNA577649 | ENA

Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

| PRJNA577661 | ENA

Transcriptomic analysis (RNAseq) of tumour-exposed Tregs from IL33 genetical deficient mice

Project description:Our purpose was to analyse the transcriptomic profile of Tregs from tumor-draining lymph nodes of melanoma-bearing mice in order to understand the functional difference between WT and il33-/- Tregs

2019-10-16 | GSE138872 | GEO

Proteomic analysis of IL33-proximal proteins in squamous cell carcinoma cells

Project description:Focal adhesion kinase (FAK) is required for the expression of pro-inflammatory genes that inhibit anti-tumour immunity. Here, we show a novel and crucial role for the dual-function cytokine IL33 in FAK-dependent immune evasion. Specifically, nuclear FAK is required for the expression of IL33, the chemokine Ccl5 and the soluble form of the IL33 receptor, sST2, which are required for evasion of CD8+ T-cell-mediated anti-tumour immunity. Mechanistically, nuclear IL33 associates with FAK and a network of chromatin modifiers and transcriptional regulators, including Taf9, WDR82 and BRD4, while sST2 likely negates effects of IL33 secreted into the tumour microenvironment by infiltrating host immune cells. Finally, protein interaction network analysis implies that nuclear FAK–IL33 complexes impact on transcription factors that regulate NFkB and chemokines like Ccl5 downstream. Our data therefore provide new mechanistic insight into how FAK controls the tumour immune environment via a FAK–IL33/sST2 pathway and demonstrate a novel role for nuclear IL33 downstream of FAK as a component of transcription regulatory complexes that critically modulate anti-tumour immunity.

2017-12-06 | PXD007698 | Pride

Transcriptome analysis of naïve Tregs, memory Tregs and CD161+ Tregs

Project description:Transcriptome analysis of naïve Tregs, memory Tregs and CD161+ Tregs

| PRJNA489005 | ENA

ATACseq

Project description:ATACseq data for this study.

| EGAS00001007166 | EGA

Proteomic analysis of rest and activated Tregs

Project description:The aim of the project is to do proteomic analysis of total cell lysate from rest and activated mouse Tregs. The proteomic data were mapped to the Gene Ontology Cellular Component (GOCC)database to obtain the list of membrane proteins on activated Tregs. The set of membrane proteins identified were compared with the potential Siglec-1 counter-receptors on activated Tregs.

2021-04-28 | PXD022259 | Pride

ATAC-seq data from naïve Tregs, memory Tregs and CD161+ Tregs

Project description:ATAC-seq data from naïve Tregs, memory Tregs and CD161+ Tregs

| PRJNA489004 | ENA

TIGIT+ Tregs

Project description:TIGIT+ Tregs suppress Th1 and Th17 responses while sparing Th2 responses. Analysis of global gene expression of TIGIT+ vs. TIGIT- Tregs from naive mice reveled that TIGIT+ Tregs display an activated phenotype and are enriched for Treg signature genes including the Treg effector molecule Fgl2 which enables them to selectively spare Th2 responses. TIGIT+ and TIGIT- Tregs were sorted from naïve Foxp3-GFP KI mice (pooled spleen and lymph nodes) TIGIT: T cell immunoreceptor with Ig and ITIM domains

2014-12-12 | E-GEOD-56299 | biostudies-arrayexpress

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data