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Transcriptome profiling of liver derived from calcium channel ITPR2 KO mice

ABSTRACT: Transcriptome profiling of liver derived from calcium channel ITPR2 KO mice

PROVIDER: PRJNA587751 | ENA |

REPOSITORIES: ENA

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Transcriptome profiling of liver derived from calcium channel ITPR2 KO mice

Project description:Cellular senescence is induced by multiple stresses and results in a stable proliferation arrest accompanied by a pro-inflammatory secretome. Senescent cells accumulate during aging, promoting various age-related pathologies and thus limiting lifespan. The endoplasmic reticulum ITPR2 release channel and calcium fluxes from the ER to the mitochondria have been identified as drivers of cellular senescence in human cells. Here we show that Itpr2 knockout mice display improved aging such as increased lifespan, a better response to metabolic stress, less immunosenescence, as well as less liver steatosis and fibrosis. Cellular senescence, which is known to promote these alterations, is decreased in both Itpr2 KO mice and Itpr2 KO embryo-derived cells. Interestingly, ablation of ITPR2 in vivo and in vitro decreases the number of contacts between the mitochondria and the ER and forced contacts between these two organelles induce premature senescence in normal cells. These new findings shed light on the role of contacts and facilitated exchanges between the ER and the mitochondria through ITPR2 in regulating senescence and physiological aging.

2019-11-06 | GSE139967 | GEO

Transcriptome profiling of early or late passage MEFs derived from calcium channel ITPR2 KO mice

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Transcriptome profiling of early or late passage MEFs derived from calcium channel ITPR2 KO mice

Project description:Transcriptome profiling of early or late passage MEFs derived from calcium channel ITPR2 KO mice

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Inhibiting L-type calcium channel promotes cardiomyocyte proliferation through activating canonical Wnt signaling pathway

Project description:We performed RNA-Seq analysis of neoatal rat ventricular cardiomyocytes (NRVCs) and human pluripotent stem cells derived cardiomyocytes (hPSC-CMs) which were treated with Nimodipine (NM) to investigate the moleclular mechanism of inhibiting L-type calcium channel (LTCC) to promote cardiomyocyte proliferation.

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Lack of TRPV1 Channel Modulates Mouse Gene Expression and Liver Proteome with Glucose Metabolism Changes

Project description:To investigate the role of the transient receptor potential channel vanilloid type 1 (TRPV1) channel in hepatic glucose metabolism, we performed proteomics analysis of the liver of C57Bl/6J (WT) and Trpv1 KO mice (n = 4 per group). Liver from Trpv1 KO mice showed significant proteomics changes consistent with enhanced glycogenolysis, as well as increased gluconeogenesis and inflammatory features.

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Rice Ethylene Receptors Define a Novel Plant Hormone Receptor-Ion Channel with Calcium/Cation Permeability

Project description:The gaseous phytohormone ethylene regulates pivotal plant processes from development, productivity to resistance, yet how its signaling intersects with calcium (Ca²⁺) second messengers remains elusive. Here, we identify a calcium-dependent antagonism of ethylene response (CAER) regulating root elongation in the model cereal Oryza sativa. Unexpectedly, we show that the ethylene receptor OsERS1 acts as a Ca²⁺-permeable, non-selective cation channel, mediating permeation of both mono- and divalent cations. Mutagenesis analyses reveal that OsERS1 channel activity relies on homomeric assembly sites (C4/C6) rather than its ethylene-binding domain (C65), indicating decoupled regulatory modules for receptor and channel functions. Genetic data demonstrate that, unlike wild-type plants, both the loss-of-function mutant Osers1 and gain-of-function line Osers2d fail to exhibit CAER phenotypes, establishing that CAER depends on ethylene receptors of OsERS1 and OsERS2. Our findings reveal a previously unrecognized ion-channel function of ethylene receptors, establishing a novel paradigm of "hormone receptor-type ion channel (HRIC)" in plants. This discovery carries broad implications for redefining signal transduction networks across plant biology.

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The calcium-permeable channel OSCA1.3 regulates plant stomatal immunity

Project description:Perception of biotic and abiotic stresses often leads to stomatal closure in plants. Rapid influx of calcium ions (Ca2+) across the plasma membrane plays an important role in this response, but the identity of Ca2+ channels involved has remained elusive. Here, we report that the Arabidopsis thaliana Ca2+-permeable channel OSCA1.3 controls stomatal closure during immunity. OSCA1.3 is rapidly phosphorylated upon perception of pathogen-associated molecular patterns (PAMPs). Biochemical and quantitative phospho-proteomics analyses reveal that the immune receptor associated cytosolic kinase BIK1 interacts with and phosphorylates the N-terminal cytosolic loop of OSCA1.3 within minutes of treatment with the peptidic PAMP flg22 derived from bacterial flagellin.

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The mutant Moonwalker TRPC3 channel links calcium signaling to lipid metabolism in the developing

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