Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Tet2 negatively regulates memory fidelity

ABSTRACT: Tet2 negatively regulates memory fidelity

PROVIDER: PRJNA590200 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Tet2 negatively regulates memory fidelity

Project description:Tet2 functions in the CA1 as a negative regulator of long-term memory, and its haploinsufficiency in glutamatergic neurons or knockdown across the CA1 in mice is sufficient to enhance the fidelity of hippocampal-dependent spatial and associative memory.

2022-11-16 | GSE140575 | GEO

Palmitoylation negatively regulates AEG-1 function

Project description:Palmitoylation negatively regulates AEG-1 function

| PRJNA888790 | ENA

NRDE2 negatively regulates nuclear exosome functions

Project description:NRDE2 negatively regulates nuclear exosome functions

| PRJNA491937 | ENA

NRDE2 negatively regulates nuclear exosome functions I

Project description:NRDE2 negatively regulates nuclear exosome functions I

| PRJNA491944 | ENA

NRDE2 negatively regulates nuclear exosome functions IV

Project description:NRDE2 negatively regulates nuclear exosome functions IV

| PRJNA491939 | ENA

NRDE2 negatively regulates nuclear exosome functions II

Project description:NRDE2 negatively regulates nuclear exosome functions II

| PRJNA491941 | ENA

KA120 negatively regulates effector-triggered immunity [RNA-seq]

Project description:KA120 negatively regulates effector-triggered immunity [RNA-seq]

| PRJNA616052 | ENA

Kat2a regulates hippocampal memory formation

Project description:Kat2a regulates hippocampal memory formation

| PRJNA231958 | ENA

TET2 regulates the neuroinflammatory response in microglia

Project description:TET2 regulates the neuroinflammatory response in microglia

| PRJNA414973 | ENA

TET2 Negatively Regulates Nestin Expression in Human Melanoma.

Project description:Although melanoma is an aggressive cancer, the understanding of the virulence-conferring pathways involved remains incomplete. We have demonstrated that loss of ten-eleven translocation methylcytosine dioxygenase (TET2)-mediated 5-hydroxymethylcytosine (5-hmC) is an epigenetic driver of melanoma growth and a biomarker of clinical virulence. We also have determined that the intermediate filament protein nestin correlates with tumorigenic and invasive melanoma growth. Here we examine the relationships between these two biomarkers. Immunohistochemistry staining of nestin and 5-hmC in 53 clinically annotated primary and metastatic patient melanomas revealed a significant negative correlation. Restoration of 5-hmC, as assessed in a human melanoma cell line by introducing full-length TET2 and TET2-mutated constructs, decreased nestin gene and protein expression in vitro. Genome-wide mapping using hydroxymethylated DNA immunoprecipitation sequencing disclosed significantly less 5-hmC binding in the 3' untranslated region of the nestin gene in melanoma compared to nevi, and 5-hmC binding in this region was significantly increased after TET2 overexpression in human melanoma cells in vitro. Our findings provide evidence suggesting that nestin regulation is negatively controlled epigenetically by TET2 via 5-hmC binding at the 3' untranslated region of the nestin gene, providing one potential pathway for understanding melanoma growth characteristics. Studies are now indicated to further define the interplay between 5-hmC, nestin expression, and melanoma virulence.

| S-EPMC4901139 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data