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Palmitoylation negatively regulates AEG-1 function

ABSTRACT: Palmitoylation negatively regulates AEG-1 function

PROVIDER: PRJNA888790 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR21848616.fastq.gz	Fastqsanger.gz
	SRR21848617.fastq.gz	Fastqsanger.gz
	SRR21848618.fastq.gz	Fastqsanger.gz
	SRR21848619.fastq.gz	Fastqsanger.gz
	SRR21848620.fastq.gz	Fastqsanger.gz

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Palmitoylation negatively regulates AEG-1 function

Project description:In vitro studies revealed that AEG-1 is palmitoylated at cysteine at a.a. 75 position. In order to check how palmitoylation regulates AEG-1 function in vivo we generated a knockin moue using CRISPR/Cas9 taking in which cysteine 75 was mutated to serine (AEG-1-C75S). Hepatocytes were isolated from AEG-1-WT and AEG-1C75S littermates, total RNA was isolated and RNA-sequencing was performed.

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