Project description:The beta cell mass of the adult pancreas is thought to be maintained through low-level proliferation. Ductal cells have been proposed as an alternative source of beta cells in vivo, but this remains controversial. By performing detailed lineage tracing analysis, 3D imaging and single cell RNA sequencing we investigated if ductal cells contribute to the beta cell mouse in the adult mouse.

2021-09-02 | GSE138038 | GEO

Expression data from adult mouse pancreas.

Project description:Two strains of rodent C57Bl/6J and KK/HIJ were compared to find the most suitable rodent model of obesity and type 2 diabetes. KK/HIJ become larger and glucose intolerant on standard chow but are not as well characterized as the C67Bl/6J model which has a more defined behavioral phenotype. The present study is to asses and determie the most suitable mouse model for our research. We used microarray analysis to examine changes in adult rodent pancreatic gene expression.

2021-03-16 | GSE141313 | GEO

Global gene expression in the adult Gata6 null mouse pancreas

Project description:We report the global gene expression of mouse pancreatic cells in a pancreas-specific conditional knock-out mouse for Gata6, as compared with age-matched controls. Total RNA was extracted from the pancreas of 6-8 -week old mice of the two genotypes and analyzed. at this age, Gata6P-/- pancreata are histologically normal, but the acinar differentiation programme is already altered. we observe that loss of Gata6 causes the de-repression of ectopic non-pancreatic genes, as well as some genes involved in the mesenchymal programme.

2015-02-03 | GSE47536 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data