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Expression data from human myocardial cells, AC16

ABSTRACT: Expression data from human myocardial cells, AC16

PROVIDER: PRJNA593398 | ENA |

REPOSITORIES: ENA

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Expression data from human myocardial cells, AC16

Project description:This study aimed to provide new compelling clues in the PM2.5-induced toxicity and mechanism which order the meaningful bioinformatics evidences for further study on human cardiovascular system. We used microarrays to detail the global programme of gene expression underlying cellularization and identified distinct classes of up-regulated genes after treated with chemical substance

2019-12-05 | GSE141418 | GEO

Expression data from human myocardial cells, AC16

Project description:This study aimed to provide new compelling clues in the PM2.5-induced toxicity and mechanism which order the meaningful bioinformatics evidences for further study on human cardiovascular system. We used microarrays to detail the global program of gene expression underlying cellularisation and identified distinct classes of up-regulated genes after treated with chemical substance.

2017-03-01 | GSE95506 | GEO

RNA sequencing of AC16 and AC16-CAR cells

Project description:RNA sequencing of AC16 and AC16-CAR cells

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Targeted analysis of alternative protein isoforms in AC16 cells

Project description:AC16 cells (Human Cardiomyocyte Cell Line) were digested by trypsin and analyzed by parallel reaction monitoring.

2022-05-19 | PXD023563 | Pride

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Project description:Expression data from human myocardial cells, AC16

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polysome-IP profiling experiment : Polysomes of untreated or tunicamycin-treated AC16 cells were immunoprecipitated with anti-MRPS15 antibody, followed by RNA sequencing

Project description:Polysomes of untreated (NT) or tunicamycin-treated (TM) human cardiomyocyte AC16 cells were immunoprecipitated (IP MRPS15) with anti-MRPS15 antibody, followed by RNA sequencing. As a control, RNAseq was performed on polysome-associated RNAs of untreated or tunicamycin-treated human cardiomyocyte AC16 cells before immunoprecipitation (input).

2024-04-01 | E-MTAB-13915 | biostudies-arrayexpress

Effect of homoharringtonine and Rocaglamide A on synchronized AC16 cells

Project description:Transcriptomic analysis of synchonized AC16 cells treated with homoharringtonine 1 µM or Rocaglamide A 100 nM for 4h (20h after synchronization) We used microarrays to detail the global programme of gene expression

2023-11-30 | GSE222682 | GEO

Astronauts plasma-derived exosomes induced gene expression in AC16 cells

Project description:There are unique stressors in the spaceflight environment. Exposure to such stressors is associated with adverse effects on astronauts' health, including increased cancer and cardiovascular disease risks. Small extracellular vesicles (sEVs, i.e., exosomes) play a vital role in intercellular communication and regulate various biological processes contributing to their role in disease pathogenesis. To assess whether spaceflight alters sEVs transcriptome profile, sEVs were isolated from the blood plasma of 3 astronauts at two different time points: 10 days before launch (L-10) and 3 days after return (R+3) from the Shuttle mission. Human adult ventricular cardiomyocyte cells (AC16) were treated with L-10 and R+3 astronauts-derived exosomes for 24 hours. Total RNA was isolated and analyzed for gene expression profiling using Affymetrix microarrays. Enrichment analysis was performed using Enrichr. Transcription factor enrichment analysis using the ENCODE/ChEA Consensus TF database identified gene sets related to the polycomb repressive complex 2 (PRC2) and Vitamin D receptor (VDR) in AC16 cells treated with R+3 compared to cells treated with L-10 astronauts-derived exosomes. Further analysis of the histone modifications using datasets from the Roadmap Epigenomics Project confirmed enrichment in gene sets related to the H3K27me3 repressive mark. Interestingly, analysis of previously published H3K27me3–chromatin immunoprecipitation sequencing (ChIP-Seq) ENCODE datasets showed enrichment of H3K27me3 in the VDR promoter. Collectively, our results suggest that astronaut-derived sEVs may epigenetically repress the expression of the VDR in human adult cardiomyocytes c by promoting the activation of the PRC2 complex and H3K27me3 levels.

2022-03-12 | GSE198322 | GEO

Transcriptomic profiles of synchronized AC16 cells after a kinetic exposition to digoxin

Project description:Transcriptomic analysis of synchonized AC16 cells after 0-6-12-18 or 24 h of digoxin treatment (5µM) We used microarrays to detail the global programme of gene expression

2023-11-30 | GSE222680 | GEO

Proteome adaptations of AC16 cells different oxygen exposure

Project description:To simulate in vitro different oxidative stress exposures, AC16 cells were cultured either under physioxia (5% oxygen) or normoxia (21% oxygen), and were consequently harvested either under physioxia or normoxia.

2021-09-10 | PXD023620 | Pride

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