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Next generation sequencing of human monocyte derived dendritic cells stimulated with MGL-stimulating glycodendrimers in the absence or presence of LPS

ABSTRACT: Next generation sequencing of human monocyte derived dendritic cells stimulated with MGL-stimulating glycodendrimers in the absence or presence of LPS

PROVIDER: PRJNA601333 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR10897418.fastq.gz	Fastqsanger.gz
	SRR10897419.fastq.gz	Fastqsanger.gz
	SRR10897420.fastq.gz	Fastqsanger.gz
	SRR10897421.fastq.gz	Fastqsanger.gz
	SRR10897422.fastq.gz	Fastqsanger.gz

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Next generation sequencing of human monocyte derived dendritic cells stimulated with MGL-stimulating glycodendrimers in the absence or presence of LPS

Project description:To investigate the effect of MGL ligation in monocyte-derived dendritic cell biology, we generated control dendrimers and two different glycodendrimers exposing the MGL ligands αGalNAc or GalNAcβ1-4Gal. αGalNAc and GalNAcβ1-4Gal glycodendrimers were validated in the corresponding manuscript. Monocyte-derirved dendritic cells were generated by culturing monocytes for 4 days with IL-4 and GM-CSF. To study the effect of MGL-ligation at the transcriptional level, next generation sequencing was performed on monocyte-derived dendritic cells from three independent donors, stimulated for 4 h with control, αGalNAc or GalNAcβ1-4Gal glycodendrimers in the absence or presence of LPS.

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Next-generation sequencing of human monocyte-derived dendritic cells stimulated with sialic acid glycodendrimers in the absence or presence of LPS

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