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Conversion of fibroblasts to functional Leydig like cells using defined small molecules

ABSTRACT: Conversion of fibroblasts to functional Leydig like cells using defined small molecules

PROVIDER: PRJNA608265 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11153157.fastq.gz	Fastqsanger.gz
	SRR11153158.fastq.gz	Fastqsanger.gz
	SRR11153159.fastq.gz	Fastqsanger.gz
	SRR11153160.fastq.gz	Fastqsanger.gz
	SRR11153161.fastq.gz	Fastqsanger.gz

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Conversion of fibroblasts to functional Leydig like cells using defined small molecules

Project description:we report that fibroblasts can be efficiently and directly reprogrammed into Leydig-like cells by exposing to a combination of small molecules, Forskolin, 20α-hydroxycholesterol, luteinizing hormone (LH), and SB431542. The chemical compounds induced Leydig-like cells (CiLCs) expressed steroidogenic genes, had a global gene expression profile similar to that of Leydig cell, and acquired androgen synthesis capabilities.

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