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Transcriptomic analysis of KDM4B-mediated gene in C4-2B prostate cancer cells

ABSTRACT: Transcriptomic analysis of KDM4B-mediated gene in C4-2B prostate cancer cells

PROVIDER: PRJNA614957 | ENA |

REPOSITORIES: ENA

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Transcriptomic analysis of KDM4B-mediated gene in C4-2B prostate cancer cells

Project description:Histone lysine demethylase KDM4B is often overexpressed in prostate cancer and links to poor survival outcome. Recent evidence suggests that KDM4B serves as a potential therapeutic target. The global transcriptomic analysis between control and KDM4B-knockdown C4-2B cells reveals the metabolic genes involved in Warburg effect are downregulated after knocking down the expression of KDM4B, indicating its role in tumor growth.

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Expression data from prostate cancer cell lines C4-2B (enzalutamide sensitive) and C4-2B-MDVR (enzalutamide resistant) cells

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