Ontology highlight
ABSTRACT:
SUBMITTER: Kujur W
PROVIDER: S-EPMC7793296 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Kujur Weshely W Murillo Oscar O Adduri Raju S R RSR Vankayalapati Ramakrishna R Konduru Nagarjun V NV Mulik Sachin S
PLoS pathogens 20201228 12
NK cells have been shown to display adaptive traits such as memory formation akin to T and B lymphocytes. Here we show that Zika virus infection induces memory like NK cells that express CD27. Strikingly, these cells exhibit stem-like features that include expansion capacity, self-renewal pathway, differentiation into effector cells, longer telomeres and gene signature associated with hematopoietic stem cell (HSC) progenitors. This subset shared transcriptional and epigenetic changes with memory ...[more]