Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Skeletal muscle aging and pathways regulated by 15-PGDH inhibition

ABSTRACT: Skeletal muscle aging and pathways regulated by 15-PGDH inhibition

PROVIDER: PRJNA630522 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR11694846_1.fastq.gz	Fastqsanger.gz
	SRR11694846_2.fastq.gz	Fastqsanger.gz
	SRR11694847_1.fastq.gz	Fastqsanger.gz
	SRR11694847_2.fastq.gz	Fastqsanger.gz
	SRR11694848_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 26

Similar Datasets

Skeletal muscle aging and pathways regulated by 15-PGDH inhibition

Project description:To identify signalling pathways and genes regulated by 15-PGDH inhibition by SW033291

2020-12-10 | GSE149924 | GEO

Biological Aging of Human Skeletal Muscle

Project description:Biological Aging of Human Skeletal Muscle

| PRJNA728322 | ENA

Exercise Mitigates Skeletal Muscle Epigenetic Aging

Project description:Exercise Mitigates Skeletal Muscle Epigenetic Aging

| PRJNA732356 | ENA

Skeletal Muscle Transcriptome in Healthy Aging

Project description:Skeletal Muscle Transcriptome in Healthy Aging

| PRJNA690800 | ENA

Skewed macrophage polarization in aging skeletal muscle

Project description:Skeletal muscle aging is a major causative factor for disability and frailty in the elderly. Recent theories about the origins of the progressive impairment of skeletal muscle with aging emphasize a disequilibrium between damage and repair. Macrophages participate in muscle tissue repair first as pro-inflammatory M1 subtype and then as M2 anti-inflammatory subtype. However, information on macrophage presence in skeletal muscle is still sporadic and the effect of aging on different phenotypes remains unknown. In this study, we sought to characterize the polarization status of macrophages human skeletal muscle at different ages. We found that most macrophages in human skeletal muscle are M2, and that this number increased with advancing age. On the contrary, M1 macrophages decline with aging, making the total number of macrophages invariant with older age. Notably, M2 macrophages co-localized with increasing intermuscular adipose tissue (IMAT) in aging skeletal muscle. The mouse strain BALB/c, intrinsically M2-prone, showed increased IMAT and regenerating myofibers in skeletal muscle, accompanied by elevated expression of adipocyte markers and M2 cytokines. Collectively, we report that polarization of macrophages to the major M2 subtype is associated with IMAT, and propose that increased M2 in aged skeletal muscle may reflect active repair of aging-associated muscle damage.

2022-01-01 | GSE125481 | GEO

Skeletal muscle stem cell ciliary pathways

Project description:Skeletal muscle stem cell ciliary pathways

| PRJNA606745 | ENA

Effect of 15-PGDH inhibition on skeletal muscle after sciatic nerve transection by single nuclei analysis

Project description:There are currently no approved treatments for the weakness and paralysis that result from loss of peripheral nerve function with aging, trauma, or neuromuscular disease. Here we use single nuclei sequencing to show that denervation due to transection of the sciatic nerve triggers a striking increase in the prostaglandin degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in skeletal muscle.

2023-10-23 | GSE239848 | GEO

Exercise Mitigates Skeletal Muscle Epigenetic Aging

Project description:Exercise late in life mitigates skeletal muscle epigenetic aging, providing evidence that physical activity is a "fountain of youth".

2021-12-31 | GSE175410 | GEO

Skewed macrophage polarization in aging skeletal muscle

Project description:Skewed macrophage polarization in aging skeletal muscle

| PRJNA516464 | ENA

Skeletal Stem Cell Aging

Project description:Skeletal Stem Cell Aging

| PRJNA679960 | ENA