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Transcriptome analysis of C2C12 myoblasts with mutations in LMNA gene

ABSTRACT: Transcriptome analysis of C2C12 myoblasts with mutations in LMNA gene

PROVIDER: PRJNA631916 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11776837.fastq.gz	Fastqsanger.gz
	SRR11776838.fastq.gz	Fastqsanger.gz
	SRR11776839.fastq.gz	Fastqsanger.gz
	SRR11776840.fastq.gz	Fastqsanger.gz
	SRR11776841.fastq.gz	Fastqsanger.gz

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Transcriptome analysis of C2C12 myoblasts with mutations in LMNA gene

Project description:Mutations in LMNA gene cause laminopathies in human. Mostly, laminopathies alter skeletal muscle tissue and lead to cardiomathy and lipodystrophy. We investigated the effect of mutations G232E (EDMD2 syndome) and R482L (FPLD2 syndrome) in LMNA gene on skeletal muclse functioning and metabolism using transgenic C2C12 myoblast cell lines and transcriptome analysis. We found abnormalities of nuclear lamina structure in mutant myoblasts, treir pro-myogenic commitment and metabolic disregulation on all stages of transgenic myoblasts differentiation.

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Project description:We show the application of 5mC antibody-based methylated DNA immunoprecipitation followed sequencing technology for high-through profiling of DNA methylation in mouse C2C12 myoblasts and myotubes. By analyzing the methylation status of immunoprecipitated DNA fragments, we generated genome-wide DNA methyaltion maps in mouse C2C12 myoblasts and myotubes. We find that DNA methylation levels in myoblasts at rDNA promter and coding regions are higher than that in myotubes but not changed in intergenic regions.

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