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Gene expression profile at single cell level of C2C12 myoblasts bearing human LMNA gene with mutations WT, R482L

ABSTRACT: LMNA mutation R482L cause classical familial partial lipodystrophy of Dunnigan type (FPLD2). FPLD is a severe metabolic disorder that often leads to cardiovascular and skeletal muscle complications. How LMNA mutations affect functional properties of skeletal muscles is still not understood. In the present project we investigated the LMNA-R482L mutation-specific alterations in mouse C2C12 line of myoblasts using single cell RNA sequencing (scRNA-seq). We showed the heterogeneity of C2C12 myoblasts cell line prior the differentiation, and compositional and transcriptional changes in LMNA-R482L C2C12 myoblasts comparing to LMNA-WT.

ORGANISM(S): Mus musculus

PROVIDER: GSE260946 | GEO | 2025/02/02

REPOSITORIES: GEO

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