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Transcriptional changes induced by Lamin A/C downregulation in the nuclei of E0771 breast cancer cells

ABSTRACT: Transcriptional changes induced by Lamin A/C downregulation in the nuclei of E0771 breast cancer cells

PROVIDER: PRJNA634748 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11837381.fastq.gz	Fastqsanger.gz
	SRR11837382.fastq.gz	Fastqsanger.gz
	SRR11837383.fastq.gz	Fastqsanger.gz
	SRR11837384.fastq.gz	Fastqsanger.gz
	SRR11837385.fastq.gz	Fastqsanger.gz

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Transcriptional changes induced by Lamin A/C downregulation in the nuclei of E0771 breast cancer cells

Project description:Major transcriptional changes (290 differentially expressed genes) take place upon downregulation of Lamin A/C in E0771 breast cancer cells

2021-06-02 | GSE151105 | GEO

Transcriptional changes induced by Lamin A/C downregulation in the nuclei of B16F10 melanoma cells

Project description:Major transcriptional changes (300 differentially expressed genes) take place upon downregulation of Lamin A/C in B16F10 melanoma cells

2021-06-02 | GSE146730 | GEO

Transcriptional changes induced by Lamin A/C downregulation in the nuclei of B16F10 melanoma cells

Project description:Transcriptional changes induced by Lamin A/C downregulation in the nuclei of B16F10 melanoma cells

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E0771 WXS

Project description:E0771 whole exom sequencing

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Gene expression profile at single cell level of CD45+ immune cells from E0771-Vector control tumor tissue, E0771 wildtype Malt1 overexpression tumor tissue and E0771 paracaspase-deficient Malt1 overexpression tumor tissue.

Project description:To invesitigate the additional paracaspase-independent tumor-promoting effect exist for Malt1. We thus collected E0771-Vector control tumor tissue, E0771 wildtype Malt1 (Malt1-WT) overexpression tumor tissue and E0771 paracaspase-deficient Malt1 (Malt1-PD) overexpression tumor tissue, and sorted out immune cells for 10× Genomics single cell RNA-sequencing (scRNA-seq).

2024-04-18 | GSE242554 | GEO

RNA-seq of E0771-Vector control, E0771-Malt1-WT and E0771 Malt1-PD after T cell killing

Project description:RNA-seq of E0771-Vector control, E0771-Malt1-WT and E0771 Malt1-PD after T cell killing

| PRJNA1014469 | ENA

RNA-seq of E0771-Vector control, E0771-Malt1-WT and E0771 Malt1-PD (Without T cell coculture)

Project description:RNA-seq of E0771-Vector control, E0771-Malt1-WT and E0771 Malt1-PD (Without T cell coculture)

| PRJNA1015214 | ENA

Deleterious assembly of the lamin A/C mutant p.S143P causes ER stress in familial dilated cardiomyopathy

Project description:Mutation of the LMNA gene, encoding nuclear lamin A and lamin C (hereafter lamin A/C), is a common cause of familial dilated cardiomyopathy (DCM). Among Finnish DCM patients, the founder mutation c.427T>C (p.S143P) is the most frequently reported genetic variant. Here, we show that p.S143P lamin A/C is more nucleoplasmic and soluble than wild-type lamin A/C and accumulates into large intranuclear aggregates in a fraction of cultured patient fibroblasts as well as in cells ectopically expressing either FLAG- or GFP-tagged p.S143P lamin A. In fluorescence loss in photobleaching (FLIP) experiments, non-aggregated EGFP-tagged p.S143P lamin A is significantly more dynamic. In in vitro association studies, p.S143P lamin A failed to form appropriate filament structures but instead assembled into disorganized aggregates similar to those observed in patient cell nuclei. A whole genome expression analysis revealed an elevated unfolded protein response (UPR) in cells expressing p.S143P lamin A/C. Additional endoplasmic reticulum (ER) stress induced by tunicamycin reduced the viability of mutant lamin expressing cells further. In summary, p.S143P lamin A/C affects normal lamina structure and influences the cellular stress response, homeostasis and viability. Total RNA obtained from 4 control and 7 patient cell lines

2016-06-10 | E-GEOD-82290 | biostudies-arrayexpress

RNA-seq of E0771-Vector control and E0771-Malt1-WT at basal condition

Project description:To reveal the downstream signal change induced by Malt1, we collected mRNA samples from Vector control- and WT-Malt1-expressing E0771 cancer cells, and performed RNA-seq analysis.

2024-04-26 | GSE265893 | GEO

RNA-seq of E0771-Vector control, E0771-Malt1-WT and E0771 Malt1-PD (Without T cell coculture)

Project description:To reveal the downstream paracrine signals from WT-Matl1 or PD-Malt1 tumor cells which responsible for the above observed macrophage phenotypes, we collected mRNA samples from Vector control-, WT-Malt1-, PD-Malt1-, V87R-Malt1-, or L88D-Malt1-expressing E0771 cancer cells, and performed RNA-seq analysis.

2024-04-18 | GSE242878 | GEO

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