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Extended archaeal histone-based chromatin structure regulates global gene expression in Thermococcus kodakarensis

ABSTRACT: Extended archaeal histone-based chromatin structure regulates global gene expression in Thermococcus kodakarensis

PROVIDER: PRJNA637645 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR11938108.fastq.gz	Fastqsanger.gz
	SRR11938109.fastq.gz	Fastqsanger.gz
	SRR11938110.fastq.gz	Fastqsanger.gz
	SRR11938111.fastq.gz	Fastqsanger.gz
	SRR11938112_1.fastq.gz	Fastqsanger.gz

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Extended archaeal histone-based chromatin structure regulates global gene expression in Thermococcus kodakarensis

Project description:Using the model organism Thermococcus kodakarensis, we genetically alter the chromatin landscape and quantify the resultant changes in gene expression, including unanticipated and significant impacts on provirus transcription. Global transcriptome changes resultant from varying chromatin landscapes reveal the regulatory importance of higher-order histone-based chromatin architectures in regulating gene expression.

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Project description:A hyperthermophilic archaeon Thermococcus kodakarensis can grow in a wide range of temperatures from 60Â°C to 93Â°C, optimally at 85Â°C. To screen the genes that being specifically expressed at lowest growth temperature, 60Â°C, we investigated the transcriptional profilings of T. kodakarensis grown at 60ËC by comparing with those grown at 85Â°C. One-condition experiment, KU216 grown at optimal growth temperature, 85Â°C vs. KU216 grown at lowest growth temperature, 60Â°C. Technical replicates: 2 KU216 grown at 60Â°C, independently measured. One replicate per array.

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Extended Archaeal Histone-Based Chromatin Structure Regulates Global Gene Expression in <i>Thermococcus kodakarensis</i>.

Project description:Histone proteins compact and organize DNA resulting in a dynamic chromatin architecture impacting DNA accessibility and ultimately gene expression. Eukaryotic chromatin landscapes are structured through histone protein variants, epigenetic marks, the activities of chromatin-remodeling complexes, and post-translational modification of histone proteins. In most Archaea, histone-based chromatin structure is dominated by the helical polymerization of histone proteins wrapping DNA into a repetitive and closely gyred configuration. The formation of the archaeal-histone chromatin-superhelix is a regulatory force of adaptive gene expression and is likely critical for regulation of gene expression in all histone-encoding Archaea. Single amino acid substitutions in archaeal histones that block formation of tightly packed chromatin structures have profound effects on cellular fitness, but the underlying gene expression changes resultant from an altered chromatin landscape have not been resolved. Using the model organism Thermococcus kodakarensis, we genetically alter the chromatin landscape and quantify the resultant changes in gene expression, including unanticipated and significant impacts on provirus transcription. Global transcriptome changes resultant from varying chromatin landscapes reveal the regulatory importance of higher-order histone-based chromatin architectures in regulating archaeal gene expression.

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