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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (10X Genomics scRNA-seq)

ABSTRACT: Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (10X Genomics scRNA-seq)

PROVIDER: PRJNA648080 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12303200.fastq.gz	Fastqsanger.gz
	SRR12303197.fastq.gz	Fastqsanger.gz
	SRR12303198.fastq.gz	Fastqsanger.gz
	SRR12303199.fastq.gz	Fastqsanger.gz

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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity

Project description:Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity

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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (10X Genomics scRNA-seq)

Project description:Single cell sequencing of Ins2-Cre;ptdTomato+ FACS sorted cells from micro-dissected hypothalamic arcuate nucleus and median eminence of wildtype and Irx3/5 double heterozygous mice.

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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (DROP-seq)

Project description:Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (DROP-seq)

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Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity (DROP-seq)

Project description:Drop-Seq single cell RNA sequencing of hypothalamic arcuate nucleus and median eminence from wildtype and Irx3/5 double heterozygous mice

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Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

Project description:Analysis of the roles of Irx3 and Irx5 transcription factors in mouse heart development and postnatal heart function. Results show that show that Irx3 and Irx5 have redundant function in the in the endocardium to regulate atrioventricular canal morphogenesis and outflow tract formation. A postnatal deletion of Irx3 and Irx5 surprisingly results in a restoration of the repolarization gradient that is altered in Irx5 mutant hearts, suggesting a model whereby postnatal Irx3 activity is normally repressed by Irx5. 4 genotypes were analyzed: Irx5+/- (3 samples), Irx3-/-;Irx5+/- (4 samples), Irx5-/- (3 samples), Irx5-/-;Irx3-/- (4 samples). The Irx5+/- samples are the reference.

2012-06-19 | E-GEOD-38826 | biostudies-arrayexpress

Cooperative and antagonistic roles for Irx3 and Irx5 in cardiac morphogenesis and postnatal physiology

2012-06-20 | GSE38826 | GEO

Irx3 and Irx5 regulate hypothalamic postnatal neurogenesis and leptin sensitivity

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-02-18 | GSE154981 | GEO

Tao et al. BioID of Irx3 and Irx5

Project description:This submission contains the mass spectrometry files for the manuscript by Tao et al. that describes the characterization of the two transcription factors Irx3 and Irx5 and their role in regulating sister chromatid segregation. This submission contains 8 DDA files for the following baits: BirA*-FLAG-Irx3, BirA*-FLAG-Irx5, BirA*-FLAG-GFP (control) and BirA* (control).

2016-06-12 | MSV000079812 | MassIVE

Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads

Project description:Irx3 and Irx5 are important for oocyte and follicle survival within the developing ovary, but their regulation had not been elucidated. Methods: XX and XY supporting cells of the gonad were FACS-purified at E13.5, and submitted to ChIP-seq for H3K27me3 and H3 as a means to normalize across cell populations. Results: We identified TCF/LEF-binding sequences within two distal enhancers of the IrxB locus that promote β-catenin responsive ovary expression. Meanwhile, Irx3 and Irx5 transcription is suppressed within the developing testis by the presence of H3K27me3 on these same sites.

2020-03-11 | GSE146761 | GEO

Tanycyte-independent control of hypothalamic leptin signaling

Project description:Purpose: 1. Bulk-RNA-Seq was performed to identify tancytye-enriched genes. 2. scRNA-Seq was performed to profile hypothalamic cells following leptin treatment Conclusions: Leptin receptor expression in tanycytes is either absent or undetectably low, that tanycytes do not directly regulate hypothalamic leptin signaling, and that leptin regulates gene expression in diverse hypothalamic cell types through both direct and indirect mechanisms.

2019-02-19 | GSE126707 | GEO

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