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A cellular mechanism to detect and alleviate reductive stress

ABSTRACT: A cellular mechanism to detect and alleviate reductive stress

PROVIDER: PRJNA649541 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR12344611_1.fastq.gz	Fastqsanger.gz
	SRR12344611_2.fastq.gz	Fastqsanger.gz
	SRR12344612_1.fastq.gz	Fastqsanger.gz
	SRR12344612_2.fastq.gz	Fastqsanger.gz
	SRR12344613_1.fastq.gz	Fastqsanger.gz

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A cellular mechanism to detect and alleviate reductive stress

Project description:Metazoan organisms rely on conserved stress response pathways to detect and alleviate adverse conditions and preserve their cellular integrity. Stress responses are particularly important in stem cells that provide lifetime support for tissue formation and repair, yet how these protective systems are integrated into developmental programs is poorly understood. Here, we have used myoblast differentiation to identify the E3 ligase CUL2FEM1B and its substrate FNIP1 as core components of the reductive stress response. Reductive stress, as caused by prolonged antioxidant signaling or mitochondrial inactivity, reverts the oxidation of invariant Cys residues in FNIP1 and thereby allows CUL2FEM1B to recognize its target. The ensuing proteasomal degradation of FNIP1 restores mitochondrial activity to preserve both redox homeostasis and stem cell integrity. The reductive stress response is therefore built around a ubiquitin-dependent rheostat that tunes mitochondrial activity to cellular redox needs and implicates metabolic control in the coordination of stress and developmental signaling.

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Project description:Galactose catabolism in Aspergillus nidulans is regulated by at least two regulators, GalR and GalX. In Aspergillus niger only GalX is present, and its role in D-galactose catabolism in this fungus was investigated. Phenotypic and gene expression analysis of a wild type and a galX disruptant revealed that GalX does not substitute for the absence of GalR in A. niger, it regulates the D-galactose oxido-reductive pathway, but not the Leloir pathway. Four genes, including the recently characterized ladB (galactitol dehydrogenase) were found to have differencial expressions that are highly relevant to GalX , indicating a novel oxido-reductive pathway in A.niger . We aim to discover differentially expressed genes in A.niger wild type strain N402 and M-NM-^TgalX mutant while growing on galactose as carbon source. Biological duplicates were made for both strains. The strains were grown O/N in complete medium with 2% frunctose and mycelium was then washed and transferred to minimal medium with 25 mM D-galactose and incubated for 2 hours. Affymetrix microarray experiments were performed RNA isolated from these samples.

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