Feces metagenome
Ontology highlight
ABSTRACT:
PROVIDER: PRJNA655208 | ENA |
REPOSITORIES: ENA
Similar Datasets
Project description:Uncovering systemic immunological modification by type 2 diabetes mellitus in periodontitis patients via single-cell RNA analysis
| PRJNA1023400 | ENA
Project description:Diabetes mellitus (DM) after transplantation remains a crucial clinical problem in kidney transplantation. To obtain insights into molecular mechanisms underlying the development of post-transplant diabetes mellitus (PTDM) and its early impact on glomerular structures, here we comparatively analyze the proteome of histologically normal appearing glomeruli from patients with PTDM from normoglycemic (NG) transplant recipients, and from recipients with pre-existing type 2 DM (PTDM)
2023-10-24 | PXD042188 | Pride
Project description:There is a close relationship between hyperglycemia in diabetes and progression of periodontal disease. This study aims to investigate the effect of hyperglycemia on the barrier function of gingival epithelial cells as a cause of hyperglycemia-exacerbated periodontitis in diabetes mellitus. Abnormal expressions of adhesion molecules in gingival epithelium in diabetes were compared between db⁄db and control mice.
2023-07-29 | PXD035613 | JPOST Repository
Project description:Periodontitis and type Ⅱ diabetes mellitus (T2D) have emerged as prevalent global chronic diseases, with a bidirectional relationship existing between them. Individuals with periodontitis and T2D are susceptible to tooth loss, primarily attributed to alveolar bone resorption resulting from excessive osteoclasts (OC) differentiation. Although low-intensity pulsed ultrasound (LIPUS) is an established treatment method for bone-related conditions, its mechanism of action on OC remains unclear. The aim of this research is to examine the effects and mechanism of on OC within a diabetic inflammatory environment. In summary, our data explored how LIPUS affects OC in the inflammatory environment of diabetes.
2026-07-29 | GSE280908 | GEO
Project description:Type 2 diabetes mellitus represents a major health problem with increasing prevalence worldwide. Limited efficacy of current therapies have prompted a search for novel therapeutic options. Here we show that treatment of pre-diabetic mice with mitochondrially targeted tamoxifen, a potential anti-cancer agent with senolytic activity, improves glucose tolerance and reduces body weight with most pronounced reduction of visceral adipose tissue due to reduced food intake, suppressed adipogenesis and elimination of senescent cells. Glucose-lowering effect of mitochondrially targeted tamoxifen is linked to improvement of type 2 diabetes mellitus-related hormones profile and is accompanied by reduced lipid accumulation in liver. Lower senescent cell burden in various tissues, as well as its inhibitory effect on pre-adipocyte differentiation, results in lower level of circulating inflammatory mediators that typically enhance metabolic dysfunction. Targeting senescence with mitochodrially targeted tamoxifen thus represents an approach to the treatment of type 2 diabetes mellitus and its related comorbidities, promising a complex impact on senescence-related pathologies in aging population of patients with type 2 diabetes mellitus with potential translation into the clinic.
2022-05-20 | PXD031710 | Pride
Project description:Periodontitis, a chronic inflammatory disease, has been linked to various systemic conditions, including cardiovascular disease, type 2 diabetes, and premature birth. However, its impact on skeletal muscle remains unclear. Here, we utilize a ligature-induced periodontitis (LIP) mouse model and show that periodontitis significantly reduces muscle and bone mass without affecting fat mass or food intake. Interestingly, activin A, a well-documented inducer of muscle atrophy, was highly expressed in periodontitis-affected gingiva, surpassing its expression in the liver, a primary activin A-expressing organ. The activin A gene (Inhba) was highly expressed, particularly in gingival fibroblasts and epithelial cells, which undergo significant proliferation as periodontitis progresses, as well as in myeloid cells infiltrating inflamed periodontal tissues and in myeloid cell-derived osteoclasts. A similar upregulation pattern of INHBA was also confirmed in periodontitis-affected human tissues by scRNA-seq analysis. Furthermore, we demonstrate that serum activin A levels significantly increased in periodontitis-affected mice, while the intra-gingival injection of siInhba significantly reduced activin A levels and restored muscle mass and myofiber size compared to the siCtrl injection. Our findings indicate that activin A is a key mediator of muscle atrophy in periodontitis and that local injection of siInhba can prevent periodontitis-induced muscle atrophy without causing systemic adverse effects.
2026-03-23 | GSE315263 | GEO
Project description:Probiotic normalization of systemic inflammation in siblings of Type 1 diabetes patients
| PRJNA682419 | ENA
Project description:Salivary exsomal miRNAs may play important role in the pathogenesis of chronic inflammatory disease, such as periodontitis. There are many studies which suggested the connection between periodontitis and systemic disease, however, the role of specific miRNA as a intersection of periontitis and diabetes are not elucidated. We suggested miR-25-3p as possible common mediator in the pathogenesis of periodontitis and diabetes.
2021-11-20 | GSE189107 | GEO
Project description:<p>Background: This study aims to comprehensively characterize the dynamic succession of the salivary microbiome and metabolic reprogramming in type 2 diabetes mellitus (T2DM) patients across progressive stages of periodontitis (Stage I–IV) using an integrated multi-omics approach. We specifically sought to evaluate the clinical value of a salivary multi-omics-based machine learning model for the precision stratification of periodontitis severity.</p><p>Methods: Unstimulated saliva samples were collected from 120 T2DM patients stratified into four groups based on periodontitis severity (Stages I–IV, n=30 per group). 16S rDNA amplicon sequencing and LC-MS untargeted metabolomics were employed to analyze microbial and metabolic profiles. Multivariate statistics, Procrustes analysis, and Random Forest algorithms were utilized to identify key features and construct diagnostic models.</p><p>Results: Disease progression was characterized by a significant restructuring of the microbiome, featuring an increase in Firmicutes and enrichment of core pathogens (e.g., Porphyromonas, Treponema) in Stage IV. Metabolically, a stage-specific shift was observed from early amino acid perturbations to late-stage active proteolysis (accumulation of Pro-Pro dipeptides) and inflammatory lipid dysregulation. Notably, the abundance of Lactobacillus was significantly positively correlated with HbA1c levels and periodontal destruction. The Random Forest model based on these multi-omics signatures achieved an AUC of 0.961 for identifying Stage IV periodontitis.</p><p>Conclusion: This study reveals that the progression of periodontitis in T2DM patients is associated with specific remodeling of the salivary microecosystem, mechanistically driven by pathogen-induced proteolysis and dysregulated inflammatory lipid metabolism. The significant correlation between Lactobacillus and HbA1c provides novel evidence for the oral-systemic metabolic interplay. Furthermore, the high-accuracy diagnostic model validates the potential of saliva for non-invasive disease stratification.</p>
2026-05-20 | MTBLS13827 | MetaboLights