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Expression data of PRDM1α or empty vector-transduced NK92 or KHYG1 cell lines

ABSTRACT: Expression data of PRDM1α or empty vector-transduced NK92 or KHYG1 cell lines

PROVIDER: PRJNA660441 | ENA |

REPOSITORIES: ENA

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Expression data of PRDM1α or empty vector-transduced NK92 or KHYG1 cell lines

Project description:CD25 (IL2RA) is a subunit of IL2 receptor complex, which determines the sensitivity of the receptor to IL2. Here, we investigated whether PRDM1, a transcriptional repressor implicated as a tumor suppressor in NK cell malignancies, directly represses CD25 (IL2RA). Using ChIP-seq, we identified a direct binding site of PRDM1 within 1st intron of CD25 (IL2RA) in activated primary human NK cells. We used DNA microarrays on two PRDM1α transduced NK cell lines (i.e. NK92 and KHYG1) to address whether PRDM1 transcriptionally represses CD25.

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