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Differential expression of genes associated with inflammation in KC (Kupffer cells) after partial hepatoctomy

ABSTRACT: Differential expression of genes associated with inflammation in KC (Kupffer cells) after partial hepatoctomy

PROVIDER: PRJNA667933 | ENA |

REPOSITORIES: ENA

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microRNA profiles in KC (Kupffer cells) after partial hepatoctomy

Project description:microRNA profiles in KC (Kupffer cells) after partial hepatoctomy

| PRJNA667934 | ENA

mRNA and microRNA profiles in KC (Kupffer cells) after partial hepatoctomy

Project description:mRNA and microRNA profiles in KC (Kupffer cells) after partial hepatoctomy

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Differential expression of genes associated with inflammation in KC (Kupffer cells) and MNCs (blood monocytes):

Project description:Differential expression of genes associated with inflammation in KC (Kupffer cells) and MNCs (blood monocytes):

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A human iPSC-derived multilineage liver organoid model containing Kupffer cells to study human sepsis-associated liver dysfunction [hiPSC-EMP-KC-pKC]

Project description:To incorporate Kupffer cells into hiPSC-LOs, we differentiated erythro-myeloid progenitors (EMPs) from hiPSCs. We compares the gene expression profiles of hiPSC-EMPs with cord-blood hematopoietic stem and progenitor cells (CB-HSPCs); and EMP-generated Kupffer cells (EMP-KC) with human primary Kupffer cells.

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microRNA profiles in KC (Kupffer cells) and MNCs (blood monocytes):

Project description:microRNA profiles in KC (Kupffer cells) and MNCs (blood monocytes):

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Differential expression of genes associated with inflammation in KC (Kupffer cells) after partial hepatoctomy

Project description:The 70% resection promotes migration of Ly6C+CD11b+ monocytes/macrophages to the remnant liver accompanied by a reduction in its CD206+ macrophage content. Macrophage proliferation within the liver reaches maximum on day 3 after the surgery. Transcriptomic profiles of macrophages isolated from the regenerating livers reveal chemokine signaling signatures in combination with indications of the involvement in specific metabolic pathways rather than inflammatory effects or morphogenesis.

2020-10-08 | GSE159197 | GEO

Differential expression of genes associated with inflammation in KC (Kupffer cells) and MNCs (blood monocytes):

Project description:As a rule, mammalian organs contain a mixed population of macrophages from different sources of origin. It is assumed that the self-sustaining resident macrophages and the monocyte-derived transient macrophages differ by their functional properties and their roles in repair processes . The analysis of the functional features of different populations of macrophages is of significant practical importance, since macrophages are considered as therapeutic targets in various pathological conditions and as prospective basis for cell therapy products. The aim of this study was to compare gene expression profiles of the two alternative macrophage species exemplified, respectively, by Kupffer cells of the liver and monocytes of the blood.

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Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells

Project description:Self-renewing tissue-resident macrophages are thought to be exclusively derived from embryonic progenitors. However, whether circulating monocytes can also give rise to such macrophages has not been formally investigated. Here we use a new model of diphtheria toxin-mediated depletion of liver-resident Kupffer cells to generate niche availability and show that circulating monocytes engrafted in the liver, gradually adopt the transcriptional profile of their depleted counterparts and become long-lived self-renewing cells. Underlining the physiological relevance of our findings, circulating monocytes also contribute to the expanding pool of macrophages in the liver shortly after birth, when macrophage niches become available during normal organ growth. Thus, like embryonic precursors, monocytes can and do give rise to self-renewing tissue-resident macrophages if the niche is available to them. Clec4F+ Kupffer cells were isolated and sorted from livers from adult WT mice or KC-DTR or KC-DTR littermate control mice +/- 50ng DT at indicated timepoints. 19 samples (arrays) in total. RNA was isolated, amplified with Nugene pico kit, converted to cDNA and then hybridised on Affymetrix GeneChip Mouse Gene 1.0 ST Arrays.

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Stutzerimonas stutzeri KC strain:KC

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Impact of embryonically-derived Kupffer cells depletion on liver gene expression under hypercholesterolemic conditions

Project description:Kupffer cells (KCs) are the tissue resident macrophage population of the liver. With this experiment, we sought to investigate the potential consequences of decreasing embryonically-derived KC numbers on liver gene expression in the context of hypercholesterolemia. 3-month-old CD207-DTR x LDL-receptor deficient (C57BL6J background) female mice were injected with diphtheria toxin (DT) or heat-inactivated DT. Mice were then fed a cholesterol-rich diet to induce hypercholesterolemia. RNA sequencing was performed on liver RNA samples after 4 weeks of diet.

2024-09-05 | E-MTAB-12744 | biostudies-arrayexpress

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