Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

RNA-sequencing analysis of cerebral cortex in Down syndrome and controls

ABSTRACT: RNA-sequencing analysis of cerebral cortex in Down syndrome and controls

PROVIDER: PRJNA674018 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR12970036_1.fastq.gz	Fastqsanger.gz
	SRR12970036_2.fastq.gz	Fastqsanger.gz
	SRR12970037_1.fastq.gz	Fastqsanger.gz
	SRR12970037_2.fastq.gz	Fastqsanger.gz
	SRR12970038_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 10

Similar Datasets

MeRIP-sequencing analysis of cerebral cortex in Down syndrome and controls

Project description:To explore the characteristics of m6A RNA modification in the Down syndrome brain, we collected cerebral cortex tissues of the fetuses diagnosed with Down syndrome and controls respectively, and performed an optimized methylated RNA immunoprecipitation combined with deep sequencing (MeRIP-seq).

2020-11-03 | GSE160689 | GEO

MeRIP-sequencing analysis of cerebral cortex in Down syndrome and controls

Project description:MeRIP-sequencing analysis of cerebral cortex in Down syndrome and controls

| PRJNA674017 | ENA

Analysis of the Cerebral Cortex and Hippocampus Transcriptome Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome

Project description:Down syndrome is characterized by a complex phenotype that includes developmental disabilities and congenital anomalies. The molecular origin of these abnormalities is poorly understood. The objective of this study is to analyze whole transcriptome changes in the cortex and hippocampus of the Ts1Cje mouse model of Down syndrome to identify signaling pathways and cellular processes that are consistently perturbed in both brain regions. These pathways will offer a new opportunity for therapeutic interventions to improve cognition in Down syndrome. We refined the translocation breakpoints of MMU12 and MMU16 described previously and established the brain transcriptional map for both monosomic (MMU12) and trisomic (MMU16) regions in Ts1Cje mice. We showed that the hippocampus have more differentially regulated genes, however, the directions of regulation of these genes were generally similar in both brain regions. The secondary genome-wide effect implicated genes known to play major roles in cellular functions that are affected in Down syndrome. Functional analyses highlighted the importance of NFAT signaling, oxidative stress, neuroinflammation, hormone metabolism and olfactory perception via G-protein signaling. This study offers novel targets for therapeutic intervention in Down syndrome. We analyzed the cerebral cortex and hippocampus whole transcriptome from 8-10 weeks old Ts1Cje (n=6) and wild-type (n=5) using Affymetrix mouse gene 1.0 ST array. Data were normalized and analyzed to identify and accurately map genes that are significantly differentially expressed. Functional analyses were performed using GSEA and DAVID to better characterize cellular processes and pathways that are consistently affected in both brain regions.

2013-09-05 | E-GEOD-49635 | biostudies-arrayexpress

miR-3607 controls Wnt/bCat pathway to regulate cerebral cortex development

Project description:We report that miR3607 controls the embryonic cerebral cortex development by regulating neurogenesis, neuron migration and axon growth in a bCatenin signaling pathway dependent manner.

2022-01-12 | GSE135321 | GEO

Down Syndrome

Project description:Down Syndrome

| PRJNA804910 | ENA

Expression data in the cerebral cortex of postnatal Dyrk1a+/+ and Dyrk1a+/- mice

Project description:DYRK1A is a protein kinase with several roles in brain development. This kinase is involved in two intellectual disability syndromes: Down syndrome and DYRK1A haploinsufficiency syndrome. The Dyrk1a+/- mouse is a model for DYRK1A haploinsufficiency syndrome. We used microarray to evaluate the impact of DYRK1A haploinsufficiency in the development of the cerebral cortex.

2019-03-06 | GSE127707 | GEO

RNA-sequencing analysis of cerebral cortex in Down syndrome and controls

Project description:To determine the relationship between m6A modification and gene expression, we analyzed the RNA-Seq data of the same cortex tissues as MeRIP-Seq analyzed

2020-11-03 | GSE160690 | GEO

Analysis of the Cerebral Cortex and Hippocampus Transcriptome Reveals Unique Molecular Changes in the Ts1Cje Mouse Model of Down Syndrome

2013-09-05 | GSE49635 | GEO

Expression data from mouse cerebral cortex

Project description:Differential gene expression of cerebral cortex might be responsible for distinct neurovascular developments between different mouse strains We used Affymetrix microarray to explore the global gene expression patterns of mouse cerebral cortex of different mouse strains at two developmental stages Cerebral cortex from two mouse strains [C57BL/6J(B6) and C3H/J (C3H)] at post-natal day 1 (p1) and post-natal 11 weeks (11 wk) were harvested for microarray experiments

2013-10-21 | E-GEOD-46443 | biostudies-arrayexpress

miR-3607 controls Wnt/bCat pathway to regulate cerebral cortex development

Project description:miR-3607 controls Wnt/bCat pathway to regulate cerebral cortex development

| PRJNA558388 | ENA