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Genome wide sequencing analysis of primary cardiomyocytes treated with all-trans retinoic acid

ABSTRACT: Genome wide sequencing analysis of primary cardiomyocytes treated with all-trans retinoic acid

PROVIDER: PRJNA678296 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13055363.fastq.gz	Fastqsanger.gz
	SRR13055364.fastq.gz	Fastqsanger.gz
	SRR13055365.fastq.gz	Fastqsanger.gz
	SRR13055366.fastq.gz	Fastqsanger.gz
	SRR13055367.fastq.gz	Fastqsanger.gz

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Genome wide sequencing analysis of primary cardiomyocytes treated with all-trans retinoic acid

Project description:The retinoic acid (RA) signaling pathway is essential for cardiac development; however, cardiomyocytes, the main cell type of the heart, are considered to be unresposive to RA signaling. The goal of this study was to examine the effects of all-trans RA (atRA) treatment on cardiomyocytes isolated from E18.5 mouse embryos. We found that cardiomyocytes, contrary to previous findings, are indeed repsonsive to RA signaling and that many genes involved in cardiac developmental and repair processes were significantly deregulated upon atRA trearment. These findings have important implications for the heart development and regeneration fields.

2021-04-01 | GSE161429 | GEO

RIME against PBX1 protein in P19.6 mouse embryonal carcinoma cells treated for 48 hours with all-trans retinoic acid

Project description:Identification of PBX1 interactors in P19.6 mouse embryonal carcinoma cells treated for 48 hours with all-trans retinoic acid.

2017-04-03 | PXD006158 | Pride

Transcription profiling of human promyelocytic NB4 cells treated with all-trans retinoic acid

Project description:Gene expression profiles of promyelocytic NB4 cells treated with all-trans retinoic acid (ATRA, 1 microM) during short periods of time (1h30 and 3h) were performed and compared to untreated cells (vehicule control, 0,02% ethanol).

2009-02-04 | E-BASE-7 | biostudies-arrayexpress

Gene expression profile in the livers of insulin-resistant mice treated with all-trans retinoic acid

Project description:Therapeutic effect of all-trans retinoic acid on diet-induced insulin resistance was found. To explore molecules involved in this pharmacological effect, the hepatic transcriptome was analyzed.

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Project description:Effect of all trans retinoic acid and the novel retinoid, ST1926, on the profile of gene expression in F9 teratocarcinoma sublines characterized by the presence or absence of the RAR gamma nuclear retinoic acid receptor

2005-12-31 | E-MEXP-361 | biostudies-arrayexpress

Clinical Trial of All-trans-retinoic Acid, Bevacizumab and Atezolizumab in Colorectal Cancer

Project description:The main purpose of this clinical trial is to learn about the good and the bad effects of all trans retinoic acid (ATRA), atezolizumab and bevacizumab as a possible treatment for advanced colorectal patients. Participants will be treated with the following combination of these drugs: 1. ATRA will be given in a pill form to be taken twice a day at home for 7 days starting on day 1 of a cycle. 2. Atezolizumab will be given through a vein in arm or through mediport over 60-90 minutes every 2 weeks in the outpatient chemotherapy infusion centers at UTSW. 3. Bevacizumab will be given through a vein in arm or through mediport over 20-40 minutes every 2 weeks in the outpatient chemotherapy infusion centers at UTSW.

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Gene expression changes in mouse neuroepithelial organoids in response to all-trans retinoic acid.

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Project description:All-trans retinoic acid (ATRA) has been shown to have anti-proliferative effects, particularly in the context of cancer. However, the effects of ATRA on gene and microRNA expression in solid tumors have not been investigated. In this study, we performed gene expression and microRNA analysis of the squamous cell carcinoma cell line, ME180, following treatment with 10 micromolar all-trans retinoic acid (ATRA) for 1, 3, and 6 hours. Results provide insight into the temporal regulation of genes and microRNAs by retinoids.

2014-08-01 | GSE54464 | GEO

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