Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0

Transcription profiling of human promyelocytic NB4 cells treated with all-trans retinoic acid


ABSTRACT: Gene expression profiles of promyelocytic NB4 cells treated with all-trans retinoic acid (ATRA, 1 microM) during short periods of time (1h30 and 3h) were performed and compared to untreated cells (vehicule control, 0,02% ethanol).

ORGANISM(S): Homo sapiens

SUBMITTER: Fr?d?ric Pendino 

PROVIDER: E-BASE-7 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

altmetric image

Publications

Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.

Pendino Frédéric F   Nguyen Eric E   Jonassen Inge I   Dysvik Bjarte B   Azouz Abdulkader A   Lanotte Michel M   Ségal-Bendirdjian Evelyne E   Lillehaug Johan R JR  

Blood 20090130 14


Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34(+) progenitors. Furth  ...[more]

Similar Datasets

2020-11-05 | GSE155779 | GEO
2014-04-30 | GSE49516 | GEO
2008-11-17 | E-GEOD-11379 | biostudies-arrayexpress
2014-08-01 | GSE56739 | GEO
2022-01-31 | E-MTAB-10267 | biostudies-arrayexpress
2008-11-18 | GSE11379 | GEO
2014-04-30 | E-GEOD-49516 | biostudies-arrayexpress
2024-06-23 | PXD050317 | Pride
2014-08-01 | E-GEOD-56739 | biostudies-arrayexpress
2010-12-01 | E-GEOD-23702 | biostudies-arrayexpress