Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Fr?d?ric Pendino
PROVIDER: E-BASE-7 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Pendino Frédéric F Nguyen Eric E Jonassen Inge I Dysvik Bjarte B Azouz Abdulkader A Lanotte Michel M Ségal-Bendirdjian Evelyne E Lillehaug Johan R JR
Blood 20090130 14
Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. Using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor, retinoid-inducible nuclear factor (RINF), that contains a CXXC-type zinc-finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells and with cytokine-induced myelopoiesis of normal CD34(+) progenitors. Furth ...[more]