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High-throughput RNA sequencing analysis of mouse pre-pro-B cells and pro-B cells from wild type and Lactoferrin knockout mouse

ABSTRACT: High-throughput RNA sequencing analysis of mouse pre-pro-B cells and pro-B cells from wild type and Lactoferrin knockout mouse

PROVIDER: PRJNA684897 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13247701_1.fastq.gz	Fastqsanger.gz
	SRR13247701_2.fastq.gz	Fastqsanger.gz
	SRR13247702_1.fastq.gz	Fastqsanger.gz
	SRR13247702_2.fastq.gz	Fastqsanger.gz
	SRR13247703_1.fastq.gz	Fastqsanger.gz

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High-throughput RNA sequencing analysis of mouse pre-pro-B cells and pro-B cells from wild type and Lactoferrin knockout mouse

Project description:Purpose: The goal of this study is using RNA sequencing analysis to evaluate the role lactoferrin in the early development of B cells in mouse Methods: The pre-pro-B cells and pro-B cells were isolated from the wild type and lactoferrin knockout mice (n=3 for each group) by flow cytometry. Then the cell RNA was sequenced by the NovaSeq 6000 high-throughput sequencing service (Jingneng, Shanghai, China). Data were extracted and normalized according to the manufacturer’s standard protocol. Results: Log-fold changes of up- or down-regulated mRNAs between the control and experiment group were selected with a significance threshold of p<0.05. Conclusions: Our study describes the mRNA changes of pre-pro-B and pro-B cells from wild type and lactoferrin knockout mice

2021-04-13 | GSE163097 | GEO

High-throughput RNA sequencing analysis of mouse peritoneal cells from wild type and Lactoferrin knockout mouse during Lipopolysaccharide(LPS) stimulation

Project description:Purpose: The goal of this study is using RNA sequencing analysis to evaluate the role of lactoferrin in the LPS-induced acute inflammation in mouse Methods: 4 hs after intraperitoneal injection with LPS(4mg/kg) or equal volume PBS , the peritoneal cells were isolated from the peritoneal lavage fluid from wild type and lactoferrin knockout mice (n=3 for each group) . Then the cell RNA was sequenced by the HiSeq 2500 high-throughput sequencing service (Oebiotech, Shanghai, China). Data were extracted and normalized according to the manufacturer’s standard protocol. Results: Log-fold changes of up- or down-regulated mRNAs between the control and experiment group were selected with a significance threshold of p<0.05. Conclusions: Our study describes the mRNA expression profile changes of peritoneal cells from wild type and lactoferrin knockout mice during LPS-induced acute inflammation

2022-06-21 | GSE181752 | GEO

Transcriptome analysis of WT and lactoferrin knockout satellite cells grown for 4 days

Project description:Our phenotypic data suggest that lactoferrin knockdown reduces satellite cell proliferative capacity. The mouse muscle tissue was digested with collagenase, and satellite cells were obtained by flow sorting. We performed transcriptome analysis of wt and lactoferrin knockout cells grown for 4 days in vitro.

2022-07-13 | GSE205136 | GEO

Effect of lactoferrin treatment on iAEC2

Project description:In an attempt to understand the mode of antiviral action of lactoferrin on SARS-CoV-2 infection, we focused on the effect of lactoferrin on uninfected cells. We decided to use a physiologically relevant cell model of iPSC derived- alveolar epithelial cells (the iAEC2). We specifically focused on antiviral pathway triggered by lactoferrin on treated cells that could explain a cell-mediated effect of lactoferrin on viral replication

2021-07-15 | GSE171390 | GEO

Heterogeneity of mouse pro-epicardial cells

Project description:Heterogeneity of mouse pro-epicardial cells

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Effects of lactoferrin, sophorolipids and lactoferrin-sophorolipids-assembly on gene expression of human dermal fibroblasts (HDFn)

Project description:The aim of this study is investigate effects of lactoferrin on human dermal fibroblasts and if sophorolipids influence effects of lactoferrin on human dermal fibroblasts.

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Lactoferrin attenuated deoxynivalenol induced malfunction in mouse testis

Project description:Lactoferrin attenuated deoxynivalenol induced malfunction in mouse testis

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High-throughput RNA sequencing analysis of mouse peritoneal cells from wild type and Lactoferrin knockout mouse during Lipopolysaccharide(LPS) stimulation

Project description:High-throughput RNA sequencing analysis of mouse peritoneal cells from wild type and Lactoferrin knockout mouse during Lipopolysaccharide(LPS) stimulation

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Transcriptome analysis reveals the mechanism of bovine lactoferrin against lipopolysaccharide-induced acute lung injury

Project description:Lactoferrin (LF) is an iron-binding multifunctional cationic glycoprotein secreted by exocrine glands and neutrophils in mammals. In this study, we created a mouse model of lipopolysaccharide (LPS)-induced acute lung injury and explored the anti-inflammatory effect and mechanism of bovine lactoferrin (bLF) in acute lung injury using the RNA sequencing (RNA-seq) technology and transcriptome analysis.

2023-12-19 | GSE247266 | GEO

Effects of lactoferrin in PM2.5-induced nephrotoxicity

Project description:Several epidemiological pieces of evidence on air pollution health effects have notably accelerated in recent years. They have described the relationship between PM2.5 (ambient fine particulate matter of <2.5 μm in diameter) and kidney diseases. Previous research has shown that lactoferrin showed renoprotective effects against some kidney diseases. In the current study, we analyzed the transcriptional profiles of PM2.5 and lactoferrin using RNA sequencing (RNA-seq) and identified the key signaling pathway in the human kidney proximal tubular epithelial cell line (HK-2 cells).

2023-01-30 | GSE208331 | GEO

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