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Time course transcriptomic analysis of human melanoma A375 cells dying of immunogenic or non immunogenic apoptosis

ABSTRACT: Time course transcriptomic analysis of human melanoma A375 cells dying of immunogenic or non immunogenic apoptosis

PROVIDER: PRJNA685849 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13263700.fastq.gz	Fastqsanger.gz
	SRR13263800.fastq.gz	Fastqsanger.gz
	SRR13263701.fastq.gz	Fastqsanger.gz
	SRR13263801.fastq.gz	Fastqsanger.gz
	SRR13263702.fastq.gz	Fastqsanger.gz

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Time course transcriptomic analysis of human melanoma A375 cells dying of immunogenic or non immunogenic apoptosis

Project description:We set out to investigate the transcriptional profile of cancer cells responding to mitoxantrone (MTX) or hypericin-based photodynamic therapy (Hyp-PDT), as prototypes of immunogenic treatments compared to cisplatin (CDDP), considered a poorly immunogenic chemotherapeutic. We isolated the bulk-RNA of the treated cells, at 0 hr (untreated) and 4 hr (pre-apoptotic), 10 hr (early apoptotic) and 20 hr (late apoptotic) post-treatment, and compared it to their respective time-matched untreated controls. Differential gene expression analysis revealed that MTX and Hyp-PDT significantly upregulated the transcription of several genes as early as 4 hr post-treatment, whereas responses to CDDP treatment occurred mainly at the later time points and were associated with a predominant transcript downregulation. Bioinformatics analyses showed pathways relative to chemokine signaling and inflammation as significantly associated selectively to cells dying in an immunogenic fashion.

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