Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Pseudomonas aeruginosa strain:mPAO1

ABSTRACT: Pseudomonas aeruginosa mutS adaptation to ceftazidime-avibactam

PROVIDER: PRJNA693407 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13616100_1.fastq.gz	Fastqsanger.gz
	SRR13616100_2.fastq.gz	Fastqsanger.gz
	SRR13616200_1.fastq.gz	Fastqsanger.gz
	SRR13616200_2.fastq.gz	Fastqsanger.gz
	SRR13616300_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 728

Similar Datasets

Novel Mechanisms of Antibiotic Resistance in Mismatch Repair-Deficient Pseudomonas aeruginosa hypermutators

Project description:Using in vitro directed evolution, we show that mismatch repair-deficient Pseudomonas aeruginosa can engage novel resistance mechanisms to ceftazidime-avibactam.

2021-08-30 | GSE180086 | GEO

DNA Methyltransferase M.PaeTBCFI in a chronically adapted Pseudomonas aeruginosa strain

Project description:Pseudomonas aeruginosa is an opportunistic pathogen which causes acute and chronic infections that are difficult to treat. Comparative genomic analysis has showed a great genome diversity among P. aeruginosa clinical strains and revealed important regulatory traits during chronic adaptation. While current investigation of epigenetics of P. aeruginosa is still lacking, understanding the epigenetic regulation may provide biomarkers for diagnosis and reveal important regulatory mechanisms. The present study focused on characterization of DNA methyltransferases (MTases) in a chronically adapted P. aeruginosa clinical strain TBCF10839. Single-molecule real-time sequencing (SMRT-seq) was used to characterize the methylome of TBCF. RCCANNNNNNNTGAR and TRGANNNNNNTGC were identified as target motifs of DNA MTases, M.PaeTBCFI and M.PaeTBCFII, respectively.

2023-07-22 | GSE209530 | GEO

Pseudomonas aeruginosa strain:MPAO1

Project description:Pseudomonas aeruginosa strain:MPAO1 Genome sequencing

| PRJNA1113959 | ENA

Pseudomonas aeruginosa strain:MPAO1

Project description:Pseudomonas aeruginosa strain:MPAO1 Genome sequencing

| PRJNA923762 | ENA

Pseudomonas aeruginosa strain:MPAO1

Project description:Pseudomonas aeruginosa strain:MPAO1 Raw sequence reads

| PRJNA1134944 | ENA

Pseudomonas aeruginosa

Project description:Emergence of Ceftazidime-avibactam Resistance and Molecular Characteristics among carbapenem-resistant Pseudomonas aeruginosa Clinical Isolates

| PRJNA978265 | ENA

Adaptive responses of Pseudomonas aeruginosa to treatment with antibiotics

Project description:Circumventing or overwhelming the bacterial adaptation capabilities is key to combatting multidrug-resistant pathogens like Pseudomonas aeruginosa. In an effort to understand the physiological response of P. aeruginosa to clinically relevant antibiotics, we investigated the proteome after exposure to ciprofloxacin, levofloxacin, rifampicin, gentamicin, tobramycin, azithromycin, tigecycline, polymyxin B, colistin, ceftazidime, meropenem, and piperacillin/tazobactam. We further investigated the response to CHIR-90, which represents a promising class of lipopolysaccharide biosynthesis inhibitors currently under evaluation. Radioactive pulse-labeling of newly synthesized proteins followed by 2D-PAGE was used to monitor the acute response of P. aeruginosa to antibiotic treatment. Marker proteins were excised from non-radioactive gels and identified by mass spectrometry. The proteomic profiles provide insights into the cellular defense strategies for each antibiotic. A mathematical comparison of these response profiles based on upregulated marker proteins revealed similarities of responses to antibiotics acting on the same target area.

2021-11-29 | PXD029948 | Pride

Adaptive responses of Pseudomonas aeruginosa to treatment with antibiotics and non-steroidal anti-inflammatory drugs

Project description:Circumventing or overwhelming the bacterial adaptation capabilities is key to combatting multidrug-resistant pathogens like Pseudomonas aeruginosa. We investigated the physiological stress exerted by approved antibiotics (ciprofloxacin, levofloxacin, rifampicin, gentamicin, tobramycin, azithromycin, tigecycline, polymyxin B, colistin, ceftazidime, meropenem, piperacillin/tazobactam), experimental antibiotics (CHIR-090) and NSAIDs (acetylsalicylic acid (aspirin), diclofenac, ibuprofen), and studied the bacterial response on the proteome level. Radioactive pulse-labeling of newly synthesized proteins followed by 2D-PAGE was used to monitor the acute response of P. aeruginosa to antibiotic treatment. Subsequently, marker proteins were excised from non-radioactive gels and identified by mass spectrometry. We generated a reference library of P. aeruginosa proteomic responses and implemented a mathematical comparison of the profiles. Proteomic signatures were derived for clinically relevant target areas.

2022-08-12 | PXD022879 | Pride

Susceptibility to ceftazidime/avibactam in German MDR/XDR Pseudomonas aeruginosa

Project description:Susceptibility to ceftazidime/avibactam in German MDR/XDR Pseudomonas aeruginosa

| PRJEB30639 | ENA

Pseudomonas aeruginosa MPAO1/P1

Project description:Pseudomonas aeruginosa MPAO1 variant re-sequencing

| PRJNA80839 | ENA