Project description:How chromatin controls transcription elongation and splicing is an open question. Here we determine the transcriptomic changes of cells partially depleted of core histones. For that we construct a cell line with Doxycycline-controlled levels of the histone regulatory protein SLBP (HCT-shSLBP). HCT-shSLBP is derived from the human colon cancer cell line HCT116. Exon level and gene level transcriptomic data of Doxycycline-treated cells is compared with that non-treated cells. The final goal is to determine how chromatin depletion affects transcription and splicing.

2015-12-30 | GSE69307 | GEO

mRNA expression data for VPS39-silenced human muscle cells and controls

Project description:mRNA expression data for VPS39-silenced human muscle cells and controls

| PRJNA661033 | ENA

Maternal gene expression data from dMLL3/4-depleted Drosophila embryos

Project description:Maternal gene expression data from dMLL3/4-depleted Drosophila embryos

| PRJNA422260 | ENA