Project description:Analysis of MycER-BclXl-induced insulinoma in Fzd9 wt and knock out mice after three days of MycER activation Mice (n=4/genotype) were euthanized three days after tamoxifen inoculation and pancreatic islets were isolated and frozen at -80ºC until processing.
Project description:This study explore the role of the Myc oncogene in liver injury, in particular for the determination of the cellular programme involved in tissue repair and normalization after injury, a process that is blocked by Myc deregulation. The first objective of this study is to define the transcriptional profile of mouse livers 12 days after injury with or without MycER activation. The second objective is to determine the trancriptionl signature at 1,2,3,7 days after MycER was inactivated in pre injured liver to monitor its normalization.