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Ovis aries strain:Subo mernio | breed:Mernio sheep

ABSTRACT: Comprehensive analysis of methylome during Merino sheep hair follicle development

PROVIDER: PRJNA705405 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13809500_1.fastq.gz	Fastqsanger.gz
	SRR13809500_2.fastq.gz	Fastqsanger.gz
	SRR13809501_1.fastq.gz	Fastqsanger.gz
	SRR13809501_2.fastq.gz	Fastqsanger.gz
	SRR13809502_1.fastq.gz	Fastqsanger.gz

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Project description:We report the application of High throughout sequencing to explore the differences of skin between Super Merino sheep(SM) and Small Tail Han sheep, which have remarkable phenotype differences on wool and hair follicle traits. We analysed the expression data by CLC genomic workbench 9.0 software. We find there are 435 differential expressional genes (DEGs) (127 were up-regulated and 308 were down-regulated) when STH sheep as control group. Some hair follicle KRTs, KAPs genes and hair follicle stem cells marker genes, were up-regulated in SM sheep. However, some of mammalian epidermal development complex (EDC) family genes were up-regulated in STH sheep. The GO and gene network analysis shown high expression genes in SM sheep enriched on type I interferon, lipid/fatty acid synthesis metabolism. This study provide more details in skin which control the development of follicle and wool in sheep.

2017-11-16 | GSE95785 | GEO

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