Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mus musculus strain:C3H/HeN | isolate:Naive Resolved Sensitized

ABSTRACT: RNA-seq, ATAC-seq, WGBS, and CUT&RUN of urothelial cells isolated from Naive, Resolved, and Sensitized C3H/HeN mice

PROVIDER: PRJNA705407 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
	SRR13860200.fastq.gz	Fastqsanger.gz
	SRR13860200_1.fastq.gz	Fastqsanger.gz
	SRR13860200_2.fastq.gz	Fastqsanger.gz
	SRR13860201.fastq.gz	Fastqsanger.gz
	SRR13860201_1.fastq.gz	Fastqsanger.gz

Items per page:

1 - 5 of 180

Similar Datasets

WGBS-seq, CUTANDRUN, ATAC-seq of urothelial stem cells isolated from Juvenile Naïve C3H/HeN mice

Project description:To study epigenetic changes in mouse bladder urothelial cells with different infection histories, urothelial stem cells (USCs) isolated from C3H/HeN mice with different infection histories (Adult Naive, Resolved, and Sensitized) were used to perform WGBS , ATAC, and CUT&RUN for comparison.

2023-08-21 | GSE212094 | GEO

Lungs from ovalbumen sensitized and challenged C3H mice

Project description:Profile of gene expression in lungs of ovalbumen sensitized and challenged C3H mice. Keywords = C3H, lung, ovalbumen, mouse, Mus musculus, mice Keywords: parallel sample

2003-06-10 | GSE446 | GEO

Lungs from ovalbumen sensitized and challenged C3H mice

Project description:Profile of gene expression in lungs of ovalbumen sensitized and challenged C3H mice. Keywords = C3H, lung, ovalbumen, mouse, Mus musculus, mice

2010-06-05 | E-GEOD-446 | biostudies-arrayexpress

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [hypothalamus]

Project description:The aim of this study was to determine the impact of early life stress on the motivation for a palatable nutritional reward in two mouse strains. Our data showed that MS associated with unpredictable chronic mild stress in lactating dams exacerbated motivation for a palatable food reward (sweetened milk) in both males and females C3H/HeN mice. Interestingly, no effect of MS was reported on motivation in C57Bl/6J mice strain. The transcriptomic analysis revealed that exacerbated motivation in MS C3H/HeN male mice was associated with marked changes in gene expressions in the NAc, whereas no significant changes were reported in PFC or hypothalamus.

2023-07-24 | GSE222777 | GEO

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [nucleus accumbens]

2023-07-24 | GSE222779 | GEO

Differences in nucleus accumbens transcriptome are associated with high motivation for palatable reward in C3H/hen male mice exposed to maternal separation [medial prefrontal cortex]

2023-07-24 | GSE222780 | GEO

Se Deficiency Exacerbates Hyperoxia-Induced Lung Injury in Newborn C3H/HeN Mice

Project description:Se Deficiency Exacerbates Hyperoxia-Induced Lung Injury in Newborn C3H/HeN Mice

| PRJNA1076259 | ENA

ST105-02: Deciphering and comparison of tumor mutational burden of MBT2 and LM8 mouse cancer cell lines

Project description:The aim of this project is to use high-throughput transcriptomic approach to decipher the tumor mutational burden (TMB) of two cancer cell lines, MBT2 (urothelial) and LM8 (osteosarcoma), syngeneic of the C3H/HeN mouse strain, and to compare them as biomarker of immunogenicity (Rizvi NA et al. Science, 2015, Sha D et al. Cancer Discovery, 2020).

2024-05-31 | GSE224642 | GEO

C3H-HeH

Project description:C3H-HeH

| PRJEB10874 | ENA

Citrobacter rodentium triggers exaggerated mucosal responses in mice developing severe intestinal disease

Project description:Citrobacter rodentium is commonly used to elucidate mucosal responses to infection in mice developing mild disease (e.g. C57BL/6), while little is known about host responses to infection in mice developing severe disease (e.g. C3H/HeN). We report that the phyla Bacteroidetes is a minor component of the tissue-associated microbiome in uninfected C3H/HeN mice. Following infection, C. rodentium rapidly and uniformly colonises the C3H/HeN colonic mucosa, which coincides with downregulation of proteins involved in the TCA cycle and oxidative phosphorylation in intestinal epithelial cells (IECs). In contrast, we observed upregulation of DNA replication and DNA damage repair processes, as well as cholesterol biogenesis, import and export, nutritional immunity, IL-22 and INFg responses, and expression of NLRP3, in IECs. Moreover, C. rodentium triggers a staggered cell proliferation response from 3 days post infection, which correlated with a higher abundance of SLC5A9 and reduced abundance of the IEC differentiation markers SLC26A3 and CA4. Uniquely, C. rodentium triggers differential secretion of gel-forming mucins, with the number of goblet cells filled with acidic and neutral mucins dramatically increasing and decreasing, respectively. Together, these results show that despite vigorous responses, C3H/HeN mice succumb to C. rodentium infection, possibly as a result of excessive and disordered mucosal responses.

2020-01-21 | PXD012846 | Pride

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data