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RNA sequencing analysis for keratinocytes treated with U1 dsRNA and LL34 Alanine Scan Peptides

ABSTRACT: RNA sequencing analysis for keratinocytes treated with U1 dsRNA and LL34 Alanine Scan Peptides

PROVIDER: PRJNA705958 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR13826603_1.fastq.gz	Fastqsanger.gz
	SRR13826603_2.fastq.gz	Fastqsanger.gz
	SRR13826604_1.fastq.gz	Fastqsanger.gz
	SRR13826604_2.fastq.gz	Fastqsanger.gz
	SRR13826605_1.fastq.gz	Fastqsanger.gz

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RNA sequencing analysis for keratinocytes treated with U1 dsRNA and LL34 Alanine Scan Peptides

Project description:Summary: We looked at the global changes in gene expression in keratinlcytes treated with selected LL34 Alanine mutants and U1 dsRNA. Methods: Normal human keratinocytes were treated with 2.5 ug/ml U1 dsRNA with or with out co-treatment with LL34 Parent Peptide/ LL34 I24A or LL34 L31A for 18 h. Conclusions: Global gene expression analysis showed pathways related to Type 1 interferon signaling and cytokines where mainly repressed in cells co-treated with either LL34 I24A/ LL34 L31A peptide and U1 dsRNA in comparision to cells co-treated with LL34-Parent peptide and U1 dsRNA.

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