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Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers

ABSTRACT: Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers

PROVIDER: PRJNA714610 | ENA |

REPOSITORIES: ENA

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Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [30 cases]

Project description:Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [30 cases]

| PRJNA714599 | ENA

Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [80 cases]

Project description:Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [80 cases]

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Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [30 cases]

Project description:We conducted an epigenome-wide association study (EWAS) to evaluate global DNA methylation in EOC. In a retrospective cohort of 30 HGSOC subtype primary ovarian cancers, we observed that global DNA hypermethylation was preferentially associated with recurrent HGSOC. A total of 2,969 DMPs corresponding to 1,471 genes were involved in olfactory transduction, and calcium and cAMP signaling.

2021-08-11 | GSE168921 | GEO

Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers [80 cases]

Project description:We conducted an epigenome-wide association study (EWAS) to evaluate global DNA methylation in EOC. In a retrospective cohort of 80 primary ovarian cancers, we observed that global DNA hypermethylation was significantly associated with high-grade tumors, platinum-resistance and poor prognosis. We determined that 8,600 differentially methylated probes (DMPs) were enriched in the intergenic regions of 4,673 genes involved in small GTPases and were significantly correlated with the PI3K-AKT, MAPK, RAS, and WNT oncogenic pathways.

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Genome-wide DNA methylome analysis identifies putative biomarkers associated with the survival of human ovarian cancers

Project description:This SuperSeries is composed of the SubSeries listed below.

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Array CGH analysis of 56 primary gastric cancers for elucidating prognostic biomarkers

Project description:Array CGH analysis was done with 56 primary gastric cancers to elucidate prognostic biomarkers on the BAC basis. Using the extracted genomic DNA from 56 primary gastric cancers, array CGH was done to elucidate the prognostic biomarkers.

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Long noncoding RNA as putative biomarkers for protstate cancer detection

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Identification of putative biomarkers for Infantile Hemangiomas and Propanolol treatment via data integration

Project description:Infantile hemangiomas are the most common type of benigh tumors in early childhood, and propanolol is a standard treatment with yet unknown mechanism of action. In this study, we identify putative biomarkers for infantile hemangioma stages (proliferative and involution) in the context of propanolol treatment.

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