Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Chip-seq For Meis2 on embryonic (E16) and adult DRG

ABSTRACT: Chip-seq For Meis2 on embryonic (E16) and adult DRG

PROVIDER: PRJNA716263 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Chip-seq For Meis2 on embryonic (E16) and adult DRG

Project description:The goal was to identify DNA binding sites for the transcription factor Meis2 in native embryonic day 16 (E16) and adult sensory neurons from dorsal root ganglion (DRGs).

2021-12-01 | GSE169319 | GEO

Adult DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

Project description:Adult DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

| PRJNA544198 | ENA

Stability of the neuronal fate determinant MEIS2 is controlled by calpain2

Project description:Calpains are non-lysosomal, Ca2+-dependent cysteine proteases, which are associated with various cellular functions but have so far been mainly studied in the context of disease. Their contribution to homeostasis in the healthy organism is still not well understood and their substrates have remained enigmatic in most cases. In the present study, we describe a previously unrecognized role for the calpain protease calpain2 in the regulation of neuronal differentiation of adult neural stem- and progenitor cells through cleavage and elimintation of the neuronal fate determinant MEIS2. Mass spectrometry analysis was performed on immunoprecipitated MEIS2 protein to identify phosphory¬lated residues in MEIS2 and on immunoprecipitated MEIS2 incubated with native porcine calpain2 to map calpain2-induced cleavage sites in the protein.

2024-02-08 | PXD036442 | Pride

E18.5 DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

Project description:E18.5 DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

| PRJNA544211 | ENA

TRPV1 DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

Project description:TRPV1 DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

| PRJNA544199 | ENA

Touch receptor end-organ innervation and function requires sensory expression of the transcription factor Meis2

Project description:To better understand the molecular changes underlying tactile defects in Meis2 mutant mice, we performed bulk RNAseq analysis on Dorsal Root Ganglia (DRG) dissected form WT, Isl1Cre/+ and Isl1Cre/+::Meis2LoxP/LoxP E18.5 embryos

2024-02-21 | GSE223788 | GEO

Single cell RNAseq Adult Mouse Lumbar Dorsal Root Ganglia (DRG)

Project description:Single cell RNAseq was performed on naïve adult mouse lumbar dorsal root ganglia (DRG) cells. Neuronal and non-neuronal cell populations were identified.

2023-03-07 | GSE198485 | GEO

Adult DRG: Identification of a sacral, visceral sensory transcriptome in embryonic and adult mice

Project description:Visceral sensory neurons encode distinct sensations from healthy organs and initiate pain states that are resistant to common analgesics. Transcriptome analysis is transforming our understanding of sensory neuron subtypes but has generally focused on somatic sensory neurons or the total population of neurons in which visceral neurons form the minority. Our aim was to define transcripts specifically expressed by sacral visceral sensory neurons, as a step towards understanding the unique biology of these neurons and potentially lead to identification of new analgesic targets for pelvic visceral pain. Our strategy was to identify genes differentially expressed between sacral dorsal root ganglia (DRG) that include somatic neurons and sacral visceral neurons, and adjacent lumbar DRG that comprise exclusively somatic sensory neurons. This was performed in male and female mice (adult and E18.5). By developing a method to restrict analyses to nociceptive Trpv1 neurons, a larger group of genes were detected as differentially expressed between spinal level. We identified many novel genes not previously been associated with pelvic visceral sensation or nociception. Limited sex differences were detected across the transcriptome of sensory ganglia, but more were revealed in sacral levels and especially in Trpv1 nociceptive neurons. These data will facilitate development of new tools to modify mature and developing sensory neurons and nociceptive pathways.

2020-03-02 | GSE131619 | GEO

Comparison of wild type and Tmem184b mutant adult DRG

Project description:Comparison of wild type and Tmem184b mutant adult DRG

| PRJNA645875 | ENA

RNA-Seq based gene expression profiling of mouse Meis1-Meis2 double KO or wild-type atria and ventricles (Adult).

Project description:The goal of this study was to compare the gene expression profile, using RNA-seq technology, of mouse Meis1-Meis2 double KO or wild-type fetal or adult hearts.

2024-09-01 | GSE213357 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data