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ADAMTS13 deficiency promotes platelet accumulation in pyrrolizidine alkaloids-induced liver injury

ABSTRACT: ADAMTS13 deficiency promotes platelet accumulation in pyrrolizidine alkaloids-induced liver injury

PROVIDER: PRJNA721305 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14212128_1.fastq.gz	Fastqsanger.gz
	SRR14212128_2.fastq.gz	Fastqsanger.gz
	SRR14212129_1.fastq.gz	Fastqsanger.gz
	SRR14212129_2.fastq.gz	Fastqsanger.gz
	SRR14212130_1.fastq.gz	Fastqsanger.gz

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Similar Datasets

ADAMTS13 deficiency promotes platelet accumulation in pyrrolizidine alkaloids-induced liver injury

Project description:RNA-seq was employed to detect hepatic differential expression genes between pyrrolizidine alkaloids-induced liver injury mice and the untreated ones.

2021-04-13 | GSE171874 | GEO

Gene expression changes in rat lung induced by six pyrrolizidine alkaloids

Project description:Pyrrolizidine alkaloids (PAs) are secondary plant metabolites that can be found worldwide. They can have an impact to human health by inducing acute toxic effects like veno-occlusive disease in the liver and pulmonary arterial hypertension in the lung. The study focuses on the identification of gene expression changes in vivo in rat lungs after treatment with six structurally different PAs (echimidine, heliotrine, lasiocarpine, senecionine, senkirkine or platyphylline). Rats were treated by gavage daily with 3.3 mg/kg body weight PAs for 28 days. After this subacute exposure the transcriptional changes in the lung were investigated by whole genome microarray analysis. Transcriptomic analysis with six structurally different PA heliotrine, echimidine, lasiocarpine, senecionine, senkirkine, and platyphylline after subacute treatment of rats

2021-06-30 | GSE166195 | GEO

Gene expression changes in rat lung induced by six pyrrolizidine alkaloids

Project description:Gene expression changes in rat lung induced by six pyrrolizidine alkaloids

| PRJNA699571 | ENA

Iron deficiency, platelets and thromboembolism in cancer patients

Project description:Primary objectives: To evaluate the effect of iron therapy on platelet counts in patients with colorectal cancer and iron deficiency Primary endpoints: drop in platelet counts>10%

| 2531118 | ecrin-mdr-crc

Alkaloids modify the poison frog proteome

Project description:Poison frogs sequester chemical defenses from their diet of leaf litter arthropods for defense against predation. Little is known about the physiological adaptations that confer this unusual bioaccumulation ability. We conducted an alkaloid-feeding experiment with the Diablito poison frog (Oophaga sylvatica) to determine how quickly alkaloids are accumulated and how toxins modify frog physiology using quantitative proteomics. Diablito frogs rapidly accumulated the alkaloid decahydroquinoline within four days, and dietary alkaloid exposure modified protein abundance in the intestines, liver, and skin. Many proteins that increased in abundance with toxin accumulation are plasma glycoproteins, including the complement system and the toxin-binding protein saxiphilin. Other protein classes that change in abundance with toxin accumulation are membrane proteins involved in small molecule transport and metabolism. Overall, this work shows poison frogs can rapidly accumulate alkaloids, which alter carrier protein abundance, initiate an immune response, and alter small molecule transport and metabolism dynamics across tissues

2021-01-25 | PXD021216 | Pride

Comparative transcriptomic analysis reveal the regulation mechanism underlying MeJA-induced accumulation of alkaloids in Dendrobium officinale

Project description:Comparative transcriptomic analysis reveal the regulation mechanism underlying MeJA-induced accumulation of alkaloids in Dendrobium officinale

| PRJNA513345 | ENA

Salicylic acid accumulation is required for Fe-deficiency responses in Arabidopsis

Project description:Several phytohormones and other small molecules have been demonstrated to be involved in iron (Fe) homeostasis. However, how salicylic acid (SA), an essential hormone in plant immunity and defense responses, participates in Fe-deficiency responses in plants is largely unknown. Here, we took advantage of a SA biosynthesis defect mutant phytoalexin deficient 4 (pad4: T-DNA Salk_089936) to explore the possible effects of endogenous SA on the morphological and physiological responses to Fe deprivation. Under a Fe-deficiency treatment, Col-0 showed more severe leaf chlorosis and root growth inhibition compared with the pad4 mutant. The soluble Fe concentrations were significant higher in pad4 than Col-0 under the Fe-deficiency treatment, suggesting that a mutation in the PAD4 gene may alleviate the Fe-deficiency-induced symptoms by regulating the soluble Fe concentrations. Furthermore, a SA signaling maker line (PR1promoter: GUS) was used to investigate how Fe deficiency affects endogenous SA biosynthesis and metabolism. The data showed that Fe deficiency significantly induced SA accumulation in Col-0, and the loss function of PAD4 blocked this process. The requirement of endogenous SA accumulation for Fe-deficiency responses was confirmed using a series of SA biosynthetic mutants and transgenic lines.

2016-10-01 | GSE74515 | GEO

Crtc1 deficiency aggravates fat accumulation in the white adipose tissue

Project description:Crtc1 deficiency aggravates fat accumulation in the white adipose tissue

| PRJNA660732 | ENA

CD74 deficiency impairs Treg accumulation and function in the tumor

Project description:CD74 deficiency impairs Treg accumulation and function in the tumor

| PRJNA954341 | ENA

Quantitative Proteomic Analysis of Catharanthus roseus with Induction of Indole Alkaloids

Project description:Catharanthus roseus produces a variety of indole alkaloids with significant biological activities. The indole alkaloids including catharanthine, vindolinine, ajmalicine and the precursor strictosidine were dramatically induced in the leaves following binary stress. To profile the modification of indole alkaloids in C. roseus seedlings under the binary stress of ultraviolet-B irradiation and dark incubation, gel-free proteomic analysis was carried out to uncover the underlying molecular mechanism.

2015-08-24 | PXD001937 | Pride

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