Project description:We restored liver function in the spleen by direct reprogramming splenic fibroblasts in situ and thereby transformed the spleen into a “liver” with sufficient physiological functions within a living animal.

2021-04-17 | GSE172243 | GEO

Transforming the Spleen into a Functioning Liver In Vivo

Project description:Transforming the Spleen into a Functioning Liver In Vivo

| PRJNA473807 | ENA

Reprogramming the spleen into a functioning “liver” in vivo I

2021-04-17 | GSE172242 | GEO

Reprogramming the spleen into a functioning “liver” in vivo III

2021-04-17 | GSE172244 | GEO

Transforming the Spleen into a Functioning Liver In Vivo

Project description:We demonstrate a different strategy that successfully transformed an existing, functionally dispensable organ to regenerate another, functionally vital one in the body. Specifically, we injected STH into the mouse spleen to remodel its tissue structure, and implanted in there human or rat liver cell lines. The remodeled spleen developed an immunosuppressive, yet highly vascularized microenvironment, in which the trans-species cells proliferated fast and developed the functions of the human liver through 8 weeks, without exerting adverse responses.

2018-05-31 | GSE115107 | GEO

Reprogramming the spleen into a functioning “liver” in vivo

Project description:This SuperSeries is composed of the SubSeries listed below.

2021-04-17 | GSE172245 | GEO

Spleen and Liver

Project description:Spleen and Liver

| PRJNA99521 | ENA