Transforming the Spleen into a Functioning Liver In Vivo

ABSTRACT: We demonstrate a different strategy that successfully transformed an existing, functionally dispensable organ to regenerate another, functionally vital one in the body. Specifically, we injected STH into the mouse spleen to remodel its tissue structure, and implanted in there human or rat liver cell lines. The remodeled spleen developed an immunosuppressive, yet highly vascularized microenvironment, in which the trans-species cells proliferated fast and developed the functions of the human liver through 8 weeks, without exerting adverse responses.

ORGANISM(S): Mus musculus

PROVIDER: GSE115107 | GEO | 2018/05/31

REPOSITORIES: GEO