Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Whole blood gene expression profiling at day 1, 3 and 7 after total-body irradiation in Gottingen minipigs

ABSTRACT: Whole blood gene expression profiling at day 1, 3 and 7 after total-body irradiation in Gottingen minipigs

PROVIDER: PRJNA725499 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Whole blood gene expression profiling at day 1, 3 and 7 after total-body irradiation in Gottingen minipigs

Project description:Gottingen minipigs mirror the physiological radiation response observed in humans and hence make an ideal candidate model for studying radiation biodosimetry for both limited-sized and mass casualty incidents. We examined the whole blood gene expression profiles at day 1, 3 and 7 after total-body irradiation with 1.7, 1.9, 2.1 and 2.3 Gy doses of gamma-rays. Blood taken one day prior to radiation served as control. Six animals per dose group were used The minipigs were monitored for up to 45 days or time to euthanasia necessitated by radiation effects. Survival correlative signatures were identified from the data.

2022-04-25 | GSE173427 | GEO

Gene expression profiles from heart, lung and liver samples of total body irradiated minipigs

Project description:The present work identified gene expression changes in response to total body irradiation (TBI) in heart, lungs, and liver tissue in Gottingen minipigs. Animals were exposed to 1.7 Gy, 1.9 Gy, 2.1 Gy and 2.3 Gy of TBI and were followed for 45 days. Organ samples were collected at the end of 45 days or sooner if the animal displayed morbidity necessitating euthanasia. RNA was extracted and gene expression profiling studied using Agilent arrays.

2021-04-27 | GSE173425 | GEO

NHP gene expression after 4 Gy total body irradiation.

Project description:In the current study, we investigated the gene expression response of blood cells of non-human primates that were total body irradiated with a 4 Gy dose. We isolated total RNA from peripheral blood at 3 days before irradiation, and then from the same animals on days 3, 5 and 7 days after irradiation. Using Agilent Rhesus microarrays, we identified genes that were significantly differentially expressed across the 7-day time course of this study. We identified common biological functions affected that persisted across the 7-day study.

2023-03-29 | GSE113478 | GEO

Total-body irradiation dose response

Project description:Duplicate hybridizations with fluorochrome switching were performed following the first two fractions of total body irradiation for accumulated doses of 1.5 Gy and 3.0 Gy. Control samples for all hybridizations were from the same patient before the beginning of treatment. Keywords: dose response

2004-06-17 | GSE1366 | GEO

NHP gene expression after 4 Gy total body irradiation.

Project description:NHP gene expression after 4 Gy total body irradiation.

| PRJNA451211 | ENA

Total-body irradiation dose response

2010-06-09 | E-GEOD-1366 | biostudies-arrayexpress

Mouse bone marrow stromal cells: before or after total body irradiation

Project description:Comprehensive gene expression analysis in BM-resident stromal cells was performed for an overview of BM environmental change caused by total body irradiation (TBI). Total RNA samples collected from BM-resident stromal cells with or without TBI were subjected to high sensitivity DNA microarray assays Three-condition experiment: Unirradiated, 1 day after TBI and 3 days after TBI. Bone marrow stromal cells were obtained from C57BL/6 mice (n = 6) either non-irradiated or after 9.5 Gy irradiation at indicated times.

2016-09-01 | E-GEOD-72235 | biostudies-arrayexpress

Gene Expression Profiling in Non-Human Primate Ileum after Total-Body Irradiation

Project description:This is an experiment to study the effects of total body irradiation on intestinal gene expression. There are 24 male animals in the study; 4 controls, 10 animals received 6.7 Gy, 10 received 7.4 Gy. Animals were killed 4, 7 or 12 days after irradiation

2015-10-17 | GSE74109 | GEO

Gene Expression Profiling in Non-Human Primate Colon after Total-Body Irradiation

2015-10-17 | GSE74108 | GEO

Gene Expression Profiling in Non-Human Primate Jejunum after Total-Body Irradiation

2015-10-17 | GSE74107 | GEO