Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Common features of aging fail to occur in Drosophila raised without a bacterial microbiome

ABSTRACT: Common features of aging fail to occur in Drosophila raised without a bacterial microbiome

PROVIDER: PRJNA731913 | ENA |

REPOSITORIES: ENA

ACCESS DATA

Json Xml

Similar Datasets

Common features of aging fail to occur in Drosophila raised without a bacterial microbiome

Project description:By comparing the transcriptomes of Drosophila raised either under conventional conditions or in the complete absence of bacteria, we find that 70% of the transcriptional changes that normally occur with age are actually adaptive responses to the microbiome, not unavoidable features of aging. In the germ-free state, these seemingly ‘age-dependent’ gene expression changes never happen.

2021-05-22 | GSE174854 | GEO

Common features of aging fail to occur in <i>Drosophila</i> raised without a bacterial microbiome.

Project description:Lifespan is limited both by intrinsic decline in vigor with age and by accumulation of external insults. There exists a general picture of the deficits of aging, one that is reflected in a pattern of age-correlated changes in gene expression conserved across species. Here, however, by comparing gene expression profiling of Drosophila raised either conventionally, or free of bacteria, we show that ∼70% of these conserved, age-associated changes in gene expression fail to occur in germ-free flies. Among the processes that fail to show time-dependent change under germ-free conditions are two aging features that are observed across phylogeny, declining expression of stress response genes and increasing expression of innate immune genes. These comprise adaptive strategies the organism uses to respond to bacteria, rather than being inevitable components of age-dependent decline. Changes in other processes are independent of the microbiome and can serve as autonomous markers of aging of the individual.

| S-EPMC8246586 | biostudies-literature

Fecal samples from pasture-raised pigs

Project description:Fecal samples from pasture-raised pigs Metagenome

| PRJNA857725 | ENA

Epigenome analysis of cohorts infants and toddlers: children raised in orphanages and children raised in biological families

Project description:Genome wide DNA methylation profiling of whole blood cells. The the Illumina Infinium MethylationEPIC microarray was used. Two children's cohorts were studied: 29 children residing in the orphanages (institutional care group, IC) and 29 children being raised in biological families (biological family care group, BFC)

2019-01-21 | GSE118940 | GEO

Mitoprotein-induced stress launches a global transcriptional fail-safe program

Project description:Mitoprotein-induced stress launches a global transcriptional fail-safe program

| PRJNA480037 | ENA

Epigenome analysis of cohorts infants and toddlers: children raised in orphanages and children raised in biological families

Project description:Epigenome analysis of cohorts infants and toddlers: children raised in orphanages and children raised in biological families

| PRJNA487365 | ENA

Expression data from D. melanogaster raised on glucose-enriched or unmodified holidic food II

Project description:We used microarrays to examine transcriptional profiles of female flies raised on either a glucose-enriched (100 g/L) or unmodified holidic diet. We found several diet-dependent effects including increased growth pathway and immunity expression in flies raised on a glucose-enriched diet.

2020-03-20 | GSE147237 | GEO

Genome-wide Expression Differences in Colonocytes Isolated From Conventionally Raised or Germfree Mice

Project description:Microarray transcriptome analysis of colonocytes from conventionally raised and germfree mice.

2011-03-15 | GSE27950 | GEO

Genome-wide Expression Differences in Colonocytes Isolated From Conventionally Raised or Germfree Mice

Project description:Microarray transcriptome analysis of colonocytes from conventionally raised and germfree mice. 12 samples were analyzed, with 6 germfree (GF) samples vs. 6 conventionally raised (CONV) samples.

2011-03-15 | E-GEOD-27950 | biostudies-arrayexpress

Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution

Project description:Aging Fly Cell Atlas Identifies Exhaustive Aging Features at Cellular Resolution

| PRJNA904763 | ENA