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ABSTRACT: Nutrition during early development and pregnancy (NuPED) cohort

PROVIDER: PRJNA735618 | ENA |

REPOSITORIES: ENA

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			Action	DRS
	SRR14746235.fastq.gz	Fastqsanger.gz
	SRR14746236.fastq.gz	Fastqsanger.gz
	SRR14746237.fastq.gz	Fastqsanger.gz
	SRR14746238.fastq.gz	Fastqsanger.gz
	SRR14746239.fastq.gz	Fastqsanger.gz

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Project description:Nutrition during early development and pregnancy (NuPED) cohort

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Maternal Nurtritional Programming in the Ovine Mammary Gland

Project description:Developmental programming is the concept that environmental factors, particularly during foetal life, can alter development, metabolism and physiology of an organism and this can have consequences later in life. There is growing interest in developmental programming in livestock species, particularly effects of maternal pregnancy nutrition, which is easy to manipulate. Recent research, using a sheep model, has shown that milk production in ewe offspring may be susceptible to maternal nutritional programming, such that over nutrition (ad libitum) of the pregnant dam, compared with maintenance nutrition, may impair their first lactation performance and result in the weaning of lighter lambs. RNA-seq was performed to identify gene expression differences as a result of maternal nutrition in ewe offspring during their first parity. Samples were collected in late pregnancy and during lactation, allowing us to examine gene expression changes during maturation of the ovine mammary gland. Three biological replicates were sequenced for each of the treatment conditions (maternal nutrition: sub-maintenance, maintenance, and ad libitum) and time points (late pregnancy and lactation). Each biological replicate consisted of RNA from multiple individuals (late pregnancy n=3, lactation n=2).

2015-07-29 | E-GEOD-71424 | biostudies-arrayexpress

Maternal Nurtritional Programming in the Ovine Mammary Gland

2015-07-29 | GSE71424 | GEO

Maternal diet induces persistent DNA methylation changes in the muscle of beef calves

Project description:Maternal nutrition during pregnancy can induce epigenetic alterations in the fetal genome, such as changes in DNA methylation. It remains unclear whether these epigenetic alterations due to changes in maternal nutrition are transitory or persist over time. As such, this study was specially designed to determine whether DNA methylation modifications induced by maternal nutrition persist over time.

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Identification and Comparative Analyses of Myocardial miRNAs Involved in Fetal Response to Maternal Undernutrition

Project description:Poor maternal nutrition during pregnancy causes intrauterine growth retardation, which, in turn, is associated with increased risk of cardiovascular and metabolic diseases in later life

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Project description:Cork Nutrition Cohort

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Proteomics of the placenta of yak in the early, middle and later stages of pregnancy studies the reproductive physiological mechanism of yak pregnancy, and provides relevant theoretical data for the growth and development of the placenta

Project description:The placental histological data of yak in the early, middle and later stages of pregnancy, screening the ways to participate in the regulation of the dynamic development of yak placenta during pregnancy, and exploring the potential function of placental proteins in placenta tissue, in order to provide theoretical basis for clarifying the biological function and mechanism of placental proteins in the early and middle stages of pregnancy.

2023-03-16 | PXD040910 |

The Amniotic Fluid Proteome Changes Across Gestation in Humans and Rhesus Macaques

Project description:Amniotic fluid is a complex biological medium that offers mechanical protection and nutrition to the fetus, and also plays a key role in normal fetal growth, organogenesis, and potentially fetal programming. Amniotic fluid is also critically involved in longitudinally shaping the in utero milieu during pregnancy. Yet, the molecular mechanism of action by which amniotic fluid regulates fetal development is ill-defined partly due to an incomplete understanding of the evolving composition of the amniotic fluid proteome. Prior research consisting of cross-sectional studies suggests that the amniotic fluid proteome changes as pregnancy advances, yet longitudinal alterations have not been confirmed because repeated sampling is prohibitive in humans. We therefore performed serial amniocenteses at early, mid, and late gestational time-points within the same pregnancies in a rhesus macaque model. Longitudinally-collected rhesus amniotic fluid samples were paired with gestational-age matched cross-sectional human samples. Utilizing LC-MS/MS isobaric labeling quantitative proteomics, we demonstrate considerable cross-species similarity between the amniotic fluid proteomes and large scale gestational-age associated changes in protein content throughout pregnancy. This is the first study to establish a reference proteomic profile across gestation. This non-human primate model holds promise as a translational platform for amniotic fluid studies and to identify adversely affected pregnancies.

2023-10-24 | PXD043519 | Pride

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Project description:Enhanced nutrition during the early calfhood period has been shown to hasten the onset of puberty in heifer calves. The hypothalamic-pituitary-ovarian biochemical signalling axis regulates reproductive development in heifers, with the dynamics of gonadotropin pulsatility within the anterior pituitary gland, in particular, central to final sexual maturity. However, the precise molecular mechanisms regulating the influence of metabolic status on this signalling axis in heifer calves is yet to be fully elucidated. The objective of this study was to determine the effect of an enhanced plane of nutrition during early life, up to 21 weeks of age, on the anterior pituitary gland proteome of heifer calves. Heifer calves were offered either a high or moderate plane of nutrition. Pathway analysis of differentially abundant proteins highlighted an effect on both growth hormone and GnRH signalling pathways, as well as an effect towards reproductive system development and function

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Extracellular vesicle-enriched miRNA profiles across pregnancy in the MADRES cohort

Project description:We describe changes in miRNA in early and late pregnancy from the MADRES cohort of primarily low-income Hispanic women based in Los Angeles, CA. miRNA derived from extracellular-vesicles (EVs) were isolated from maternal blood plasma samples collected in early and late pregnancy. In this study, we identified 64 of 130 detectable miRNA which significantly increased with the gestational age (GA), and 26 which decreased with GA. Possible fetal sex-specific associations were observed for 30 of these 90 significant miRNA. Predicted gene targets for miRNA significantly associated with GA were identified using MirDIP and were found to be enriched for Gene Ontology categories that included energetic and metabolic processes but were underrepresented in immune-related categories. Circulating EV-associated miRNA during pregnancy are likely important for maternal-fetal communication, and may play roles in supporting and maintaining a healthy pregnancy, given the changing needs of the fetus.

2021-04-27 | GSE168788 | GEO

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